{"id":"W1969714585","doi":"10.1074/jbc.m006518200","title":"Chromaffin Cell F-actin Disassembly and Potentiation of Catecholamine Release in Response to Protein Kinase C Activation by Phorbol Esters Is Mediated through Myristoylated Alanine-rich C Kinase Substrate Phosphorylation","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"MARCKS; Phosphorylation; Protein kinase C; Chromaffin cell; Phorbol; Myristoylation; Biology; Cell biology; Actin; Secretion; Biochemistry; Adrenal medulla; Catecholamine; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001214599,0.0002921049,0.0002905057,0.0001766053,0.000136147,0.0002394728,0.0001054815,0.0001831623,0.0008841943],"category_scores_gemma":[0.0001090192,0.0001454272,0.0002991243,0.0001234935,0.0002190852,0.0001664209,0.000161689,0.0004944003,0.0003001905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003494076,"about_ca_system_score_gemma":0.0001662555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009052938,"about_ca_topic_score_gemma":0.001377725,"domain_scores_codex":[0.9998829,0.00001221337,0.00001084354,0.00002339182,0.00002716241,0.00004339175],"domain_scores_gemma":[0.9998924,0.00001229963,0.00002910515,0.00001353493,0.00001133188,0.00004135781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009272003,0.00001284806,0.00006646198,0.00001370698,0.000002097142,0.00002443072,0.000003060264,0.000006645783,0.9994565,0.00001199964,0.00001077839,0.000298723],"study_design_scores_gemma":[0.00003119069,0.0002836089,0.01799012,0.000003304259,0.00001454763,0.0002369051,0.00001316711,0.0004821256,0.9799889,0.00002268043,0.0009283251,0.000005031819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995939,0.001621296,0.001194848,0.00008849231,0.00003564668,0.00002836764,0.0002114796,0.00004540058,0.0008354108],"genre_scores_gemma":[0.9954823,0.001140838,0.00127681,0.00004964154,0.00002804803,0.00002560562,0.0004104982,0.0000104462,0.001575777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009052938,"threshold_uncertainty_score":0.00295794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01162050926808509,"score_gpt":0.2405258861015403,"score_spread":0.2289053768334552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}