{"id":"W1969714585","doi":"10.1074/jbc.m006518200","title":"Chromaffin Cell F-actin Disassembly and Potentiation of Catecholamine Release in Response to Protein Kinase C Activation by Phorbol Esters Is Mediated through Myristoylated Alanine-rich C Kinase Substrate Phosphorylation","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"MARCKS; Phosphorylation; Protein kinase C; Chromaffin cell; Phorbol; Myristoylation; Biology; Cell biology; Actin; Secretion; Biochemistry; Adrenal medulla; Catecholamine; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005200177,0.0002069366,0.0002716712,0.00005837566,0.00004606339,0.00002376188,0.0001321925,0.0003355419,0.00003777653],"category_scores_gemma":[0.0005232433,0.0001780847,0.00007558487,0.0003145649,0.00006009101,0.00002892366,0.00004567302,0.0001973922,0.000001034428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006993944,"about_ca_system_score_gemma":0.00007767814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002445733,"about_ca_topic_score_gemma":0.000001328313,"domain_scores_codex":[0.9985114,0.0001388195,0.0006390904,0.0002961101,0.0002062071,0.0002083924],"domain_scores_gemma":[0.998841,0.00004145151,0.0006014034,0.0001648804,0.0002180774,0.0001331735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003660455,0.000227995,0.001715999,0.00003666026,0.00001792748,0.00002609992,0.00007201222,0.0001134772,0.9935169,4.197659e-7,0.0001352774,0.0004767571],"study_design_scores_gemma":[0.001500387,0.0004525223,0.008298803,0.00009282758,0.0000123353,0.00002665028,0.0001394271,0.00007779145,0.9885023,0.00002374152,0.0006761706,0.0001970429],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975548,0.000607036,0.0009384454,0.0005302226,0.0000165526,0.0002713575,0.00002445048,0.000008302149,0.00004884904],"genre_scores_gemma":[0.9989296,0.0001732843,0.0004486768,0.0001109776,0.00005070357,0.00001259312,0.0001652112,0.00001484002,0.00009408298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006582804,"threshold_uncertainty_score":0.7262084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01162050926808509,"score_gpt":0.2405258861015403,"score_spread":0.2289053768334552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}