{"id":"W1969738534","doi":"10.1016/j.toxlet.2014.01.035","title":"Involvement of activating ERK1/2 through G protein coupled receptor 30 and estrogen receptor α/β in low doses of bisphenol A promoting growth of Sertoli TM4 cells","year":2014,"lang":"en","type":"article","venue":"Toxicology Letters","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":126,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"National Natural Science Foundation of China","keywords":"GPER; Sertoli cell; Estrogen receptor; MAPK/ERK pathway; Signal transduction; Cell growth; Cell biology; Internal medicine; Endocrinology; Receptor; Chemistry; Biology; Spermatogenesis; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001169096,0.000263004,0.0002052608,0.0002165893,0.0002250592,0.0002201269,0.0001929041,0.0002615661,0.002260903],"category_scores_gemma":[0.000111867,0.0001646095,0.0003566371,0.0001449642,0.0001855255,0.0002255729,0.0001655071,0.00045327,0.0002959551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002198079,"about_ca_system_score_gemma":0.0004531354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001808948,"about_ca_topic_score_gemma":0.002522471,"domain_scores_codex":[0.9998914,0.00002323384,0.00001149998,0.00001350552,0.00002521475,0.00003512453],"domain_scores_gemma":[0.9999387,0.00001446015,0.000009983562,0.000008661553,0.00001028581,0.00001790681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004935656,0.0001016355,0.0003297158,0.00005921533,0.000008725819,0.00007994585,0.00002661485,0.00008529464,0.9974353,0.00014071,0.00006742987,0.001171929],"study_design_scores_gemma":[0.00006416331,0.0006872387,0.009815924,0.000006882711,0.00003865683,0.0001796339,0.0001179577,0.001033523,0.9852672,0.0001080436,0.002674409,0.000006391995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966274,0.0007802757,0.001019354,0.0001709223,0.00004801304,0.0000187811,0.000229133,0.00003313568,0.001072945],"genre_scores_gemma":[0.9938692,0.0009086267,0.001079005,0.00007047479,0.000009881252,0.00004076042,0.0005537586,0.000008298176,0.003460048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002260903,"threshold_uncertainty_score":0.007563472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007873011615922444,"score_gpt":0.2640036723160262,"score_spread":0.2561306607001037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}