{"id":"W1969752754","doi":"10.1124/dmd.108.023499","title":"Identification of Ginkgo biloba as a Novel Activator of Pregnane X Receptor","year":2008,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Killam Trusts; National Institutes of Health; Michael Smith Health Research BC; GlaxoSmithKline","keywords":"Pregnane X receptor; Ginkgo biloba; CYP3A4; Pharmacology; Ginkgoales; Activator (genetics); Chemistry; Gene expression; Nuclear receptor; Receptor; Biology; Cytochrome P450; In vitro; Biochemistry; Transcription factor; Biological activity; Gene; Metabolism; Pharmacognosy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000501611,0.0002178351,0.0004234907,0.0001957994,0.0001853175,0.000008195849,0.0001911097,0.0001761586,0.0002349563],"category_scores_gemma":[0.0000679216,0.0002073592,0.0001253087,0.0003159239,0.0003432039,0.000234051,0.00007076624,0.0002434725,0.00002719585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001149781,"about_ca_system_score_gemma":0.0000799781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005248344,"about_ca_topic_score_gemma":8.816065e-7,"domain_scores_codex":[0.998308,0.0002191076,0.0006343566,0.0003230873,0.0002571442,0.0002583143],"domain_scores_gemma":[0.9987848,0.000126582,0.0004468818,0.0002264172,0.0002115096,0.0002037825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003867033,0.0006296749,0.0009139635,0.00009759487,0.0001161893,0.000002086984,0.001744392,0.00006205287,0.9818006,0.00636097,0.0005618166,0.007324029],"study_design_scores_gemma":[0.002062446,0.00002742898,0.01697974,0.00001963962,0.0003113106,0.00002801442,0.0001200158,0.0004447463,0.9576243,0.0005542487,0.02161604,0.0002120563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903003,0.006244209,0.0004364029,0.0002705961,0.0009707438,0.0004091752,0.0004940507,0.00003540104,0.0008391436],"genre_scores_gemma":[0.9937649,0.00478867,0.0003057372,0.0002646632,0.0002185346,0.00004501011,0.0001023789,0.00002266914,0.0004873841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02417621,"threshold_uncertainty_score":0.8455862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05127372640614435,"score_gpt":0.3686362813520587,"score_spread":0.3173625549459143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}