{"id":"W1969754337","doi":"10.1016/j.bmcl.2007.12.013","title":"Targeting ACE and ECE with dual acting inhibitors","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Reaction Mechanisms","field":"Chemistry","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Chemistry; Enzyme inhibitor; Pharmacology; ACE inhibitor; Stereochemistry; Enzyme; Biochemistry; Angiotensin-converting enzyme; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003815921,0.0004780425,0.000461962,0.0002305681,0.0001266661,0.0006327538,0.0003668796,0.0004376445,0.001884294],"category_scores_gemma":[0.0002120634,0.000205466,0.0002554457,0.0001364467,0.0002050042,0.000528187,0.0003409176,0.0009676219,0.0006523264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000336292,"about_ca_system_score_gemma":0.0001557894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001428609,"about_ca_topic_score_gemma":0.0003422225,"domain_scores_codex":[0.999836,0.00003112638,0.00000926135,0.00002701631,0.00004213729,0.00005432001],"domain_scores_gemma":[0.99993,0.00001939503,0.00001640287,0.000007676901,0.000009300219,0.00001720355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001111808,0.0002331472,0.0004508622,0.0002450283,0.00007111423,0.0005176938,0.00004091543,0.001521931,0.9349646,0.006638574,0.001612553,0.05259189],"study_design_scores_gemma":[0.0002238373,0.0007609818,0.0005360859,0.00001054272,0.00007649666,0.001391608,0.00001699264,0.004948923,0.959121,0.0008077008,0.03208972,0.00001600699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8313963,0.04374792,0.08599436,0.002424497,0.0007865584,0.0002812537,0.0005015386,0.0006387964,0.03422879],"genre_scores_gemma":[0.9683382,0.008343872,0.008213943,0.0003368171,0.0001438914,0.00008755065,0.0002417402,0.00003066565,0.01426324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001884294,"threshold_uncertainty_score":0.006303549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006546239030506034,"score_gpt":0.2125975440026509,"score_spread":0.2060513049721448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}