{"id":"W1969789267","doi":"10.1021/bi010158b","title":"Investigating the Role of Histidine 157 in the Catalytic Activity of Human Cytomegalovirus Protease","year":2001,"lang":"en","type":"article","venue":"Biochemistry","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences","keywords":"Proteases; Catalytic triad; Mutant; Serine protease; Serine; Chemistry; Protease; PMSF; Histidine; Biochemistry; Enzyme; Stereochemistry; Oxyanion hole; Residue (chemistry)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002032819,0.0002063334,0.0002001233,0.00007426707,0.00009159526,0.0002250882,0.0002300511,0.0003218686,0.0005217905],"category_scores_gemma":[0.0001998501,0.00007240815,0.0001832904,0.00009482127,0.0001918463,0.000251548,0.00009189657,0.0003436065,0.0001869928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002939967,"about_ca_system_score_gemma":0.0002179002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005425711,"about_ca_topic_score_gemma":0.0003319457,"domain_scores_codex":[0.9999279,0.00001164856,0.000005645673,0.00001480302,0.00002287206,0.00001713607],"domain_scores_gemma":[0.9999506,0.00001676493,0.00001131226,0.000003757702,0.000005663392,0.00001178362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003141176,0.00005998099,0.001655413,0.00007655087,0.00001255822,0.0002362782,0.00003395218,0.0004223316,0.993997,0.000488379,0.00002639895,0.002677065],"study_design_scores_gemma":[0.00003155681,0.0004240126,0.00781058,0.000008009015,0.00002362547,0.0004867062,0.00004377854,0.003063427,0.9869696,0.0001919996,0.000940205,0.000006493288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976163,0.001179497,0.0007588486,0.00003962457,0.00000822099,0.000004210448,0.00002845348,0.000004521866,0.000360379],"genre_scores_gemma":[0.9980865,0.0006380795,0.0008617028,0.0000157124,0.000003841367,0.000003030162,0.0000773685,0.000002175784,0.0003116218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005425711,"threshold_uncertainty_score":0.002133131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03356098024359769,"score_gpt":0.3171595725556241,"score_spread":0.2835985923120264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}