{"id":"W1969830786","doi":"10.1002/art.11355","title":"Gene deletion of either interleukin‐1β, interleukin‐1β–converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy","year":2003,"lang":"en","type":"article","venue":"Arthritis & Rheumatism","topic":"Knee injuries and reconstruction techniques","field":"Medicine","cited_by":212,"is_retracted":false,"has_abstract":true,"ca_institutions":"Shriners Hospitals for Children - Canada","funders":"","keywords":"Osteoarthritis; Cartilage; Nitric oxide synthase; Aggrecanase; Chondrocyte; Pathology; Medial collateral ligament; Knockout mouse; Immunostaining; Type II collagen; Medicine; Biglycan; Aggrecan; Anatomy; Proteoglycan; Nitric oxide; Immunohistochemistry; Endocrinology; Internal medicine; Ligament; Decorin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007594955,0.000254423,0.0007365258,0.0002753905,0.00009947277,0.00002534772,0.000115697,0.000196314,0.000413365],"category_scores_gemma":[0.00009760153,0.0001666813,0.0001508584,0.0004445834,0.0004400016,0.0001697196,0.00006199902,0.000302482,0.00000110391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008780995,"about_ca_system_score_gemma":0.0002641162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002836048,"about_ca_topic_score_gemma":0.001037534,"domain_scores_codex":[0.9970827,0.0002834704,0.001603632,0.0003156101,0.0004120141,0.0003025689],"domain_scores_gemma":[0.9988416,0.0001968999,0.0005021374,0.0002261299,0.000147924,0.00008532925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003333251,0.000618024,0.07089151,0.0005636814,0.0003724323,0.00006500366,0.01677506,0.00001105556,0.4854938,0.0002660271,0.00004842846,0.4215617],"study_design_scores_gemma":[0.004371297,0.0006244507,0.02252799,0.0031279,0.00005192927,0.0005468028,0.00107518,0.00002447114,0.9671305,0.0001323488,0.0001900479,0.0001970255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964491,0.002015009,0.00009133959,0.0001279576,0.0003238752,0.0008562968,0.00002042129,0.00002613466,0.00008985297],"genre_scores_gemma":[0.9969266,0.0009432439,0.001808503,0.00002448202,0.0000408954,0.0001990778,0.000007209009,0.00002736645,0.00002260317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4816368,"threshold_uncertainty_score":0.6797067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01088394216216827,"score_gpt":0.2386323556339608,"score_spread":0.2277484134717926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}