{"id":"W1969830786","doi":"10.1002/art.11355","title":"Gene deletion of either interleukin‐1β, interleukin‐1β–converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy","year":2003,"lang":"en","type":"article","venue":"Arthritis & Rheumatism","topic":"Knee injuries and reconstruction techniques","field":"Medicine","cited_by":212,"is_retracted":false,"has_abstract":true,"ca_institutions":"Shriners Hospitals for Children - Canada","funders":"","keywords":"Osteoarthritis; Cartilage; Nitric oxide synthase; Aggrecanase; Chondrocyte; Pathology; Medial collateral ligament; Knockout mouse; Immunostaining; Type II collagen; Medicine; Biglycan; Aggrecan; Anatomy; Proteoglycan; Nitric oxide; Immunohistochemistry; Endocrinology; Internal medicine; Ligament; Decorin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003544264,0.001144357,0.0005954579,0.000737772,0.0001908448,0.0004285819,0.0003557558,0.0004657786,0.001412712],"category_scores_gemma":[0.0002240954,0.0005406059,0.0004611893,0.0002021878,0.0005861192,0.0004412098,0.0002481809,0.0007664337,0.0004421818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002875063,"about_ca_system_score_gemma":0.0003150062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004770217,"about_ca_topic_score_gemma":0.0009071857,"domain_scores_codex":[0.9995725,0.00005284493,0.00006428514,0.0001049177,0.00009890439,0.0001066841],"domain_scores_gemma":[0.9989856,0.00006226287,0.0005722989,0.00005246355,0.00005080134,0.0002765085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003786485,0.00008098718,0.0004193163,0.00003651502,0.000009192506,0.00007459188,0.00001741662,0.00003658586,0.9984812,0.0000400136,0.00001500324,0.0004106558],"study_design_scores_gemma":[0.0002459944,0.003741893,0.02570158,0.0000569467,0.0001281293,0.001303776,0.0001276945,0.000995469,0.9660872,0.00008297256,0.001507081,0.00002122507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973983,0.000818594,0.001056024,0.00004897083,0.00002049464,0.0000223479,0.0002386797,0.00007248561,0.0003242829],"genre_scores_gemma":[0.9911539,0.001400686,0.002736161,0.00006666309,0.00002699887,0.0000916551,0.0007148533,0.00005838929,0.003750584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001412712,"threshold_uncertainty_score":0.004725993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01088394216216827,"score_gpt":0.2386323556339608,"score_spread":0.2277484134717926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}