{"id":"W1969836953","doi":"10.1016/j.bmcl.2014.12.028","title":"Aza follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 1: Mitigating the genotoxic liability of an aniline metabolite","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"Boehringer Ingelheim","keywords":"Chemistry; Pharmacology; Metabolite; NS5B; Potency; Stereochemistry; Polymerase; In vivo; Biochemistry; In vitro; Hepacivirus; Enzyme; Genotype; Medicine; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001870642,0.0002667868,0.0005148148,0.0002396869,0.0002981056,0.0002250163,0.0003784165,0.0004068961,0.006675798],"category_scores_gemma":[0.0004010884,0.0001185021,0.0003861282,0.0001960248,0.0001517424,0.000230206,0.0001511078,0.0005957533,0.0007711631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002550037,"about_ca_system_score_gemma":0.0002590271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001260234,"about_ca_topic_score_gemma":0.002575283,"domain_scores_codex":[0.9998734,0.00002906616,0.000009294879,0.00002276654,0.00001860363,0.00004690192],"domain_scores_gemma":[0.9998947,0.00002395316,0.0000205135,0.00001893803,0.00001425439,0.00002753371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02624923,0.003210061,0.004540064,0.0003920327,0.0004048383,0.0008852172,0.0001730895,0.002346514,0.7571622,0.0004726141,0.005128512,0.1990355],"study_design_scores_gemma":[0.003099792,0.08350182,0.06511604,0.00009456339,0.0009833989,0.00279512,0.0001827704,0.004116433,0.8105549,0.0005145714,0.02894033,0.0001004519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887009,0.004518898,0.000872054,0.0002843015,0.0001478927,0.0001679,0.0008925733,0.0001523449,0.004263028],"genre_scores_gemma":[0.9919454,0.001623254,0.0004759635,0.0001785198,0.00003084212,0.00005171807,0.0009902543,0.00002088708,0.004683152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006675798,"threshold_uncertainty_score":0.02233279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01725262029614741,"score_gpt":0.2775113293132946,"score_spread":0.2602587090171472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}