{"id":"W1969842340","doi":"10.1016/s0002-9440(10)64815-8","title":"Matrix Metalloproteinase 9 Promoter Activity Is Induced Coincident with Invasion during Tumor Progression","year":2000,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"National Cancer Institute; Medical Research Council; National Institutes of Health; Medical Research Council Canada","keywords":"Biology; Transgene; Cancer research; Genetically modified mouse; Molecular biology; Mammary gland; Matrix metalloproteinase; Reporter gene; Pathology; Gene expression; Cancer; Gene; Breast cancer; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002928918,0.0001714897,0.0003012272,0.00007275896,0.0000758427,0.00001474488,0.0001717145,0.00006525443,0.0001028719],"category_scores_gemma":[0.0000282904,0.0001223906,0.0001072563,0.0001132559,0.0001280913,0.0000161213,0.00005487864,0.0002194698,0.00001063852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002442829,"about_ca_system_score_gemma":0.0001284349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009614018,"about_ca_topic_score_gemma":0.00000297192,"domain_scores_codex":[0.9988014,0.0002053583,0.0002589948,0.000252577,0.0002072361,0.0002744183],"domain_scores_gemma":[0.9990686,0.000004490055,0.0004315921,0.0002476697,0.0001028139,0.0001448461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001164601,0.0001350996,0.000359417,0.000009382496,0.00003877108,0.0009405614,0.00008308619,0.000002677904,0.9756234,0.000001618538,0.00002551425,0.02161583],"study_design_scores_gemma":[0.000820788,0.006338921,0.001583977,0.00006315971,0.00003480436,0.005266054,0.0000544126,0.000003847326,0.9852397,0.00003200868,0.0004009278,0.0001613707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999037,0.0001339624,0.0002872105,0.0001991208,0.00004543462,0.0002159972,0.00000374841,0.000006420655,0.0000711292],"genre_scores_gemma":[0.996032,0.00004956844,0.003332501,0.0002227142,0.0002145019,0.00001606372,0.000002410665,0.00002418726,0.0001060407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02145446,"threshold_uncertainty_score":0.4990945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00673502348479703,"score_gpt":0.2596038961889744,"score_spread":0.2528688727041774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}