{"id":"W1969869131","doi":"10.1371/journal.pone.0073094","title":"Plasma Ceramide and Glucosylceramide Metabolism Is Altered in Sporadic Parkinson's Disease and Associated with Cognitive Impairment: A Pilot Study","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":238,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novartis Pharma; H. Lundbeck A/S; GlaxoSmithKline; Bundesministerium für Bildung und Forschung; Valeant Pharmaceuticals International; Teva Pharmaceutical Industries; National Institute on Aging; Eli Lilly and Company","keywords":"Lactosylceramide; Ceramide; Dementia; Internal medicine; Glucocerebrosidase; Cognitive decline; Endocrinology; Parkinson's disease; Sphingolipid; Disease; Medicine; Biology; Genetics; Immunology; Glycolipid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001946425,0.0002409241,0.0003638094,0.00008847513,0.00008406086,0.00008321,0.00008536576,0.00005216651,0.00002954978],"category_scores_gemma":[0.0001514762,0.0002119869,0.00002157967,0.0001290091,0.00009530257,0.00001973927,0.00009805625,0.0001312641,0.000003973239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000106194,"about_ca_system_score_gemma":0.00004846038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002690187,"about_ca_topic_score_gemma":0.0001344864,"domain_scores_codex":[0.9985778,0.0001221782,0.0002235623,0.0005121346,0.0002360452,0.0003283329],"domain_scores_gemma":[0.9993216,0.00003804687,0.000106831,0.0001852608,0.0001068444,0.0002413516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002319372,0.01313167,0.7590561,0.000117864,0.002078193,0.00005293115,0.001882456,0.000005781779,0.2201882,0.00001652916,0.00009472089,0.001056202],"study_design_scores_gemma":[0.007101094,0.001598772,0.9637936,0.000176128,0.0005474045,0.000002412926,0.000500071,0.0005155536,0.02525758,0.00008040799,0.00004279321,0.0003841979],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967647,0.001895172,0.000005969572,0.0000935329,0.00001976404,0.001092953,0.00006707464,0.00001920216,0.00004160365],"genre_scores_gemma":[0.998502,0.000459253,0.0001099621,0.0003765943,0.0001362198,0.0001981828,0.00008100206,0.00003641821,0.000100381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2047375,"threshold_uncertainty_score":0.8644575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0214886167088625,"score_gpt":0.2143203268804869,"score_spread":0.1928317101716244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}