{"id":"W1969903820","doi":"10.1074/jbc.m703200200","title":"The Proprotein Convertase SKI-1/S1P","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa; Montreal Clinical Research Institute","funders":"","keywords":"Transmembrane domain; Ectodomain; Furin; Kexin; Transmembrane protein; Proprotein convertase; Golgi apparatus; Cell biology; Peptide sequence; Subtilisin; Biology; Biochemistry; Endosome; Amino acid; Chemistry; Endoplasmic reticulum; Enzyme; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009787356,0.0005328376,0.0003061517,0.000270531,0.0001175085,0.0003074847,0.0001534362,0.0002304656,0.00109845],"category_scores_gemma":[0.0001347378,0.0001168344,0.0002721199,0.000174735,0.0002236077,0.0001752885,0.0001742128,0.0005146497,0.0007629007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003470631,"about_ca_system_score_gemma":0.0002480214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005171778,"about_ca_topic_score_gemma":0.0003621572,"domain_scores_codex":[0.9999266,0.000005926591,0.000006176259,0.00002080577,0.00002526956,0.00001525173],"domain_scores_gemma":[0.9998702,0.00002007735,0.00005254688,0.000009107632,0.00001584565,0.00003222875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001150986,0.00001286641,0.0005905517,0.00004927611,0.000004851357,0.0003090411,0.00001651562,0.00007428318,0.9954373,0.00008865531,0.00004209418,0.003259404],"study_design_scores_gemma":[0.000022003,0.0002530717,0.01213839,0.00001075505,0.00001515313,0.002191319,0.00004005509,0.001463907,0.9783351,0.0001345022,0.005387009,0.00000864594],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909137,0.002240432,0.005003753,0.0001059789,0.00003152219,0.00004300215,0.0005515956,0.00009078092,0.001019218],"genre_scores_gemma":[0.9833655,0.00164068,0.007659096,0.00005118425,0.00002442343,0.00003206378,0.002888184,0.00002338773,0.004315574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00109845,"threshold_uncertainty_score":0.003674686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01116371868309206,"score_gpt":0.231996311495421,"score_spread":0.2208325928123289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}