{"id":"W1969926777","doi":"10.1016/j.phytochem.2011.07.001","title":"A virus-induced gene silencing approach to understanding alkaloid metabolism in Catharanthus roseus","year":2011,"lang":"en","type":"article","venue":"Phytochemistry","topic":"Plant Virus Research Studies","field":"Agricultural and Biological Sciences","cited_by":138,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Catharanthus roseus; Vindoline; Biology; Tobacco rattle virus; Gene; Gene silencing; Indole alkaloid; Vinblastine; Biochemistry; Function (biology); Indole test; Cell biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002382369,0.0001840145,0.0002488644,0.00001992886,0.0001550005,0.00003407569,0.0003639843,0.00008688423,0.0000795652],"category_scores_gemma":[0.00009428662,0.00008350996,0.00006776294,0.0004882132,0.00004023829,0.00008961613,0.0001779977,0.0002092627,0.00002684672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000116657,"about_ca_system_score_gemma":0.00001492893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009714274,"about_ca_topic_score_gemma":0.0002176,"domain_scores_codex":[0.9985406,0.00003372634,0.0002058463,0.0004221005,0.0002780369,0.0005197332],"domain_scores_gemma":[0.9996009,0.00007322816,0.00004786794,0.00008581857,0.00002395692,0.0001682023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004678136,0.000116721,0.0001861491,0.00001249663,0.00001514702,0.00001196535,0.0007329599,0.000001313713,0.9980289,0.00003709014,0.000150827,0.0006596811],"study_design_scores_gemma":[0.0001344424,0.00002796944,0.01450012,0.00002269629,0.000006264442,0.000008897,0.001071342,0.00003216031,0.9834551,0.0003568801,0.0001488332,0.0002353376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837131,0.0003201441,0.00002051311,0.00006222451,0.00004244911,0.0002200447,0.0001420047,0.00005803529,0.01542148],"genre_scores_gemma":[0.9992477,0.00006484161,0.0002507468,0.00008490027,0.0001714063,0.00008571649,0.00003025273,0.000001647798,0.0000628328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01553455,"threshold_uncertainty_score":0.3405437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1432119794791873,"score_gpt":0.2604294627384698,"score_spread":0.1172174832592824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}