{"id":"W1969926777","doi":"10.1016/j.phytochem.2011.07.001","title":"A virus-induced gene silencing approach to understanding alkaloid metabolism in Catharanthus roseus","year":2011,"lang":"en","type":"article","venue":"Phytochemistry","topic":"Plant Virus Research Studies","field":"Agricultural and Biological Sciences","cited_by":138,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Catharanthus roseus; Vindoline; Biology; Tobacco rattle virus; Gene; Gene silencing; Indole alkaloid; Vinblastine; Biochemistry; Function (biology); Indole test; Cell biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002174211,0.0003466652,0.0002317103,0.0002581139,0.0003326363,0.0002881542,0.000456369,0.0003251013,0.0007092708],"category_scores_gemma":[0.0001237704,0.0002085408,0.0003796899,0.0001297348,0.0003279271,0.0003545197,0.0002948081,0.0008377244,0.0002874956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008873652,"about_ca_system_score_gemma":0.0003508349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003540895,"about_ca_topic_score_gemma":0.00410108,"domain_scores_codex":[0.9998803,0.00002109515,0.00001241734,0.00003875139,0.00003290519,0.00001451993],"domain_scores_gemma":[0.9998726,0.00003032612,0.00003292346,0.00001934367,0.00001933052,0.00002554173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001218968,0.000003012043,0.00002512741,0.000006274177,9.244436e-7,0.000006508557,0.000007362274,0.00002414286,0.9996202,0.00006014993,0.000003316839,0.0002308713],"study_design_scores_gemma":[0.00001307755,0.00007967321,0.002887294,0.000003313094,0.00001834739,0.000111829,0.00004565723,0.002508463,0.9926042,0.00008962573,0.001629558,0.000008933674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97421,0.001646142,0.02064428,0.0004181476,0.00004112039,0.0000847303,0.0004843591,0.0002401829,0.002230935],"genre_scores_gemma":[0.9785706,0.0009107177,0.01376347,0.0001074503,0.00001562074,0.00007164264,0.0009126479,0.0001127706,0.005535067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003540895,"threshold_uncertainty_score":0.00704056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1432119794791873,"score_gpt":0.2604294627384698,"score_spread":0.1172174832592824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}