{"id":"W1969930863","doi":"10.4161/chan.4.4.12666","title":"Characterization of a novel mutation in the cardiac ryanodine receptor that results in catecholaminergic polymorphic ventricular tachycardia","year":2010,"lang":"en","type":"article","venue":"Channels","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa; Alberta Bible College; University of Calgary","funders":"National Institutes of Health; Fondation pour la Recherche Médicale; Heart and Stroke Foundation of Canada","keywords":"Catecholaminergic polymorphic ventricular tachycardia; Ryanodine receptor; Ryanodine receptor 2; Internal medicine; Mutation; Cardiology; Ventricular tachycardia; Tachycardia; Biology; Catecholaminergic; Medicine; Receptor; Endocrinology; Genetics; Gene; Catecholamine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001283158,0.0004523758,0.0003564865,0.0004310139,0.0001662262,0.0001909318,0.0002684652,0.0006320739,0.0005948543],"category_scores_gemma":[0.0004127863,0.0001430389,0.0004089585,0.0001840954,0.0002574059,0.0001104868,0.0002095084,0.0003396503,0.0003028446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000113079,"about_ca_system_score_gemma":0.0001175121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003535473,"about_ca_topic_score_gemma":0.000345972,"domain_scores_codex":[0.9998494,0.00001949211,0.00002570079,0.0000457815,0.00004043985,0.00001914513],"domain_scores_gemma":[0.9997224,0.00008506489,0.00009345722,0.00001560319,0.00002299949,0.00006045157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001712847,0.0001183174,0.005220399,0.00004799763,0.00003506147,0.03219372,0.0001207536,0.0002093236,0.9587282,0.0001411624,0.0001223757,0.002891416],"study_design_scores_gemma":[0.0002041613,0.001751257,0.1382669,0.000059009,0.0002512868,0.3091764,0.0002900954,0.006154729,0.5357993,0.0002439112,0.007736475,0.0000664549],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969954,0.0002062305,0.002102333,0.00006179166,0.00002945924,0.00003006919,0.0002304822,0.00003483758,0.0003093318],"genre_scores_gemma":[0.997161,0.0001533392,0.001866355,0.00009388637,0.00001963054,0.0000124318,0.0003152933,0.00002957843,0.0003485296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006320739,"threshold_uncertainty_score":0.001989961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01559204724769237,"score_gpt":0.2466353013764425,"score_spread":0.2310432541287502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}