{"id":"W1969946826","doi":"10.1111/j.1753-4887.2005.tb00377.x","title":"5,10-Methylenetetrahydrofolate Reductase Polymorphisms and Pharmacogenetics: A New Role of Single Nucleotide Polymorphisms in the Folate Metabolic Pathway in Human Health and Disease","year":2005,"lang":"en","type":"review","venue":"Nutrition Reviews","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of New Brunswick; St. Michael's Hospital; University of Toronto","funders":"","keywords":"Methylenetetrahydrofolate reductase; Single-nucleotide polymorphism; Pharmacogenetics; Biology; Genetics; Metabolic pathway; B vitamins; Pharmacology; Genotype; Gene; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006741195,0.0007005555,0.00134868,0.001560157,0.000245199,0.000948582,0.0007121823,0.001616047,0.004332683],"category_scores_gemma":[0.0008567354,0.0002093559,0.0003207848,0.002376327,0.000576775,0.001370672,0.0004783169,0.001130186,0.002433547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007022712,"about_ca_system_score_gemma":0.001131997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002289535,"about_ca_topic_score_gemma":0.003249753,"domain_scores_codex":[0.9997872,0.00006074479,0.00002590737,0.0000447673,0.00006563539,0.00001577199],"domain_scores_gemma":[0.999589,0.000228039,0.00004889107,0.00001183762,0.00008899281,0.00003321602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001121803,0.00005072585,0.0005427346,0.006370243,0.00009531718,0.000414731,0.0000762736,0.0002128219,0.0024412,0.002966919,0.02278359,0.9639333],"study_design_scores_gemma":[0.00003770986,0.0001425008,0.003629373,0.003666344,0.0001686199,0.00379018,0.0001609444,0.0001210392,0.0007164504,0.005078306,0.9824612,0.00002741005],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001320268,0.9985521,0.0001143125,0.0004940229,0.00007918014,0.000001244128,0.000005903134,0.000004446378,0.0006166502],"genre_scores_gemma":[0.000808157,0.9979785,0.0002128568,0.000187025,0.0001421286,0.00000255732,0.00001256993,8.236175e-7,0.0006554408],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004332683,"threshold_uncertainty_score":0.0144943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07682850367061839,"score_gpt":0.3751188780133788,"score_spread":0.2982903743427605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}