{"id":"W1969962785","doi":"10.1016/j.febslet.2006.01.065","title":"<i>Artemisia annua</i> L. (Asteraceae) trichome‐specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin","year":2006,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":412,"is_retracted":false,"has_abstract":true,"ca_institutions":"Plant Biotechnology Institute","funders":"","keywords":"Artemisia annua; Artemisinin; Sesquiterpene lactone; Sesquiterpene; Biosynthesis; Biology; Lactone; Biochemistry; Cytochrome P450; Asteraceae; Plasmodium falciparum; Gene; Botany; Enzyme; Malaria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000479209,0.0003708815,0.0003748737,0.00006741171,0.000138142,0.00007679301,0.0007912802,0.0002312547,0.00002493544],"category_scores_gemma":[0.00004890631,0.0002244711,0.0002053093,0.000440254,0.0002667011,0.00001647517,0.0001164081,0.0002423993,0.000006970502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003008242,"about_ca_system_score_gemma":0.00006099477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008868318,"about_ca_topic_score_gemma":0.00006476208,"domain_scores_codex":[0.9977351,0.0002644619,0.0004878251,0.0005895895,0.0004262636,0.0004967378],"domain_scores_gemma":[0.9986435,0.0001124137,0.0002939366,0.000845731,0.00004981947,0.00005460344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005592505,0.0002010663,0.004710559,0.00003520364,0.00005135835,0.00003260274,0.0001219877,0.00004838326,0.9837264,0.00001063897,0.01029225,0.0002103358],"study_design_scores_gemma":[0.001041439,0.0001379623,0.05828514,0.000138705,0.00005934861,0.0001980098,0.0001789073,0.00001076558,0.9116567,0.000008373279,0.02790176,0.0003828473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936545,0.0003604841,0.00005385351,0.003837299,0.00005816844,0.0003992727,0.0002486125,0.00001468816,0.001373118],"genre_scores_gemma":[0.9972802,0.00003340881,0.0002877615,0.001426467,0.0005233812,0.00003394452,0.0001279321,0.00003173481,0.0002551776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07206962,"threshold_uncertainty_score":0.9153665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003737225848911702,"score_gpt":0.1748996199629404,"score_spread":0.1711623941140287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}