{"id":"W1969962785","doi":"10.1016/j.febslet.2006.01.065","title":"<i>Artemisia annua</i> L. (Asteraceae) trichome‐specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin","year":2006,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":412,"is_retracted":false,"has_abstract":true,"ca_institutions":"Plant Biotechnology Institute","funders":"","keywords":"Artemisia annua; Artemisinin; Sesquiterpene lactone; Sesquiterpene; Biosynthesis; Biology; Lactone; Biochemistry; Cytochrome P450; Asteraceae; Plasmodium falciparum; Gene; Botany; Enzyme; Malaria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004878757,0.0002259295,0.0001329992,0.0001421622,0.0001611833,0.0002644072,0.0001002917,0.0001793576,0.001047941],"category_scores_gemma":[0.00007736395,0.0001103873,0.0002345861,0.0001547219,0.00008406126,0.0002213246,0.0001137342,0.0003245175,0.001016132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003396716,"about_ca_system_score_gemma":0.000112598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001071335,"about_ca_topic_score_gemma":0.001356029,"domain_scores_codex":[0.9999593,0.00000436171,0.000002552747,0.00001209495,0.00001091756,0.00001067176],"domain_scores_gemma":[0.9999303,0.00001206511,0.00002105178,0.000009136575,0.00001709537,0.00001034394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002863344,0.000002596459,0.000137802,0.00001193413,0.00000140539,0.00003202117,0.00000940911,0.00002197204,0.9985937,0.00005905315,0.00004286673,0.001058415],"study_design_scores_gemma":[0.00001116106,0.0001051949,0.02679001,0.00000901844,0.00002966772,0.0009075886,0.0001078598,0.0009429205,0.9534267,0.0002008249,0.01745829,0.00001084655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807262,0.00187712,0.008323655,0.0003555218,0.00003821164,0.00002912566,0.002742431,0.0002972195,0.005610631],"genre_scores_gemma":[0.9658831,0.001438632,0.009015508,0.0002293378,0.00002398923,0.00001921575,0.01006669,0.00009156987,0.01323209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001071335,"threshold_uncertainty_score":0.003505707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003737225848911702,"score_gpt":0.1748996199629404,"score_spread":0.1711623941140287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}