{"id":"W1969983816","doi":"10.1158/1538-7445.am10-4007","title":"Abstract 4007: Cooperative regulation of Stat3 signaling by TC-PTP, SHP1, and SHP2 in keratinocytes following UVB irradiation","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Hydrogen's biological and therapeutic effects","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; McGill University","funders":"","keywords":"Dephosphorylation; Gene knockdown; Phosphorylation; Protein tyrosine phosphatase; Phosphatase; Transfection; Keratinocyte; STAT3; Biology; Molecular biology; Cell biology; Cancer research; Chemistry; Apoptosis; Biochemistry; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00116141,0.00008235906,0.0002182252,0.0001357392,0.00005365823,0.0000176091,0.00004991966,0.0001193338,0.0002152798],"category_scores_gemma":[0.0002307017,0.00006211089,0.00002741829,0.0003122253,0.0001079353,0.00007926275,0.00002106829,0.0004932943,0.000003812347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007547439,"about_ca_system_score_gemma":0.0001258124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006077796,"about_ca_topic_score_gemma":0.0003013228,"domain_scores_codex":[0.9988943,0.0001282291,0.0002237511,0.0002270853,0.0002721917,0.0002544154],"domain_scores_gemma":[0.9992916,0.0003941702,0.00003456746,0.000102381,0.00009664104,0.00008061605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001974096,0.00005944783,0.04377099,0.00005681024,0.00001837828,0.00001001541,0.0005003442,0.00006087757,0.947125,0.0001676499,0.00003442489,0.007998724],"study_design_scores_gemma":[0.002489979,0.0004079251,0.2970599,0.0003067607,0.000009512272,0.000001867426,0.0002191403,0.001949227,0.6960902,0.0007015513,0.0006328045,0.0001311231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973254,0.001206561,0.000008728094,0.0005294124,0.0000582822,0.0005016256,0.000008628988,0.000008328738,0.0003530543],"genre_scores_gemma":[0.9994522,0.0001385166,0.00007133433,0.00005783059,0.00006910032,0.00006714302,0.00002480937,0.000009021578,0.0001099995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2532889,"threshold_uncertainty_score":0.2532808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05777992245257056,"score_gpt":0.4108547825764199,"score_spread":0.3530748601238494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}