{"id":"W1969990935","doi":"10.1371/journal.pgen.1001381","title":"Genomic Instability, Defective Spermatogenesis, Immunodeficiency, and Cancer in a Mouse Model of the RIDDLE Syndrome","year":2011,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ontario Institute of Technology; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Cancer Research UK; Ontario Ministry of Health and Long-Term Care; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Genome instability; DNA damage; Biology; DNA repair; Histone; Carcinogenesis; Genetics; Cell biology; Cancer research; Molecular biology; DNA; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009853322,0.0001338768,0.0001514338,0.0000334907,0.00003554494,0.000004973606,0.0002648758,0.0001099216,0.000009817238],"category_scores_gemma":[0.00001879909,0.0001120532,0.00006156213,0.00007186461,0.0001272865,0.000002377835,0.0003639763,0.00006600238,0.00000124258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002755629,"about_ca_system_score_gemma":0.00011506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005083641,"about_ca_topic_score_gemma":0.0001731928,"domain_scores_codex":[0.9991489,0.00005663505,0.0002119198,0.0002794727,0.0001090426,0.0001940036],"domain_scores_gemma":[0.9993553,0.000004407669,0.00007902844,0.0004720701,0.00005359814,0.00003560954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002307929,0.0001373453,0.04571702,0.00003109662,0.00002840523,4.59921e-7,0.0004334282,0.0008590194,0.9525914,0.00004842052,8.901915e-7,0.0001294514],"study_design_scores_gemma":[0.0002555576,0.000094241,0.01128152,0.00001201995,0.00002634671,0.000009090352,0.00007470231,0.007086168,0.9806598,0.00035927,0.000006652294,0.0001346527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966894,0.002502133,0.00008492288,0.000005559563,0.00004017445,0.0003092313,0.00009194265,0.000006280654,0.0002703718],"genre_scores_gemma":[0.998463,0.0005834586,0.0007691658,0.00003936828,0.000006029449,0.00003845033,0.000002137646,0.0000249456,0.00007344513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0344355,"threshold_uncertainty_score":0.4569399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02600188833209786,"score_gpt":0.2223440290388075,"score_spread":0.1963421407067097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}