{"id":"W1970016764","doi":"10.1021/es505399w","title":"Isomer-Specific Binding Affinity of Perfluorooctanesulfonate (PFOS) and Perfluorooctanoate (PFOA) to Serum Proteins","year":2015,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Per- and polyfluoroalkyl substances research","field":"Environmental Science","cited_by":221,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates - Health Solutions","keywords":"Chemistry; Human serum albumin; Blood proteins; Ultrafiltration (renal); Dissociation constant; Structural isomer; Chromatography; Serum albumin; Biochemistry; Stereochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003563306,0.0003235611,0.000209508,0.0002596106,0.0001343832,0.0003402806,0.0002940802,0.0003626497,0.0004299345],"category_scores_gemma":[0.0007940794,0.0001584824,0.0002204133,0.0002168097,0.0002672547,0.0002106172,0.0001964099,0.0003139305,0.0001772396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006000429,"about_ca_system_score_gemma":0.0002468577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002355196,"about_ca_topic_score_gemma":0.002138247,"domain_scores_codex":[0.9995885,0.00006359948,0.0000239657,0.0001195597,0.0001289741,0.00007543777],"domain_scores_gemma":[0.9997638,0.00009207109,0.00004944914,0.00001291802,0.00005805821,0.00002369385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001274418,0.00001413828,0.002364835,0.00003654778,0.00001551753,0.00001674772,0.00002578208,0.0001160233,0.9945288,0.0000696591,0.00003409312,0.00265029],"study_design_scores_gemma":[0.000005572527,0.0003288133,0.01934596,0.000005688047,0.0000241646,0.0002932721,0.00005118545,0.00243666,0.9764915,0.00005525169,0.0009525814,0.000009259701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882498,0.002815489,0.007874911,0.00006092831,0.0000173092,0.00002810214,0.0001792244,0.00003598239,0.0007383571],"genre_scores_gemma":[0.9906859,0.001601715,0.006129622,0.0001010892,0.00001007312,0.00003338404,0.0003477934,0.000008382647,0.001082138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002355196,"threshold_uncertainty_score":0.004683018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02005941640051298,"score_gpt":0.2497162929662878,"score_spread":0.2296568765657748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}