{"id":"W1970016764","doi":"10.1021/es505399w","title":"Isomer-Specific Binding Affinity of Perfluorooctanesulfonate (PFOS) and Perfluorooctanoate (PFOA) to Serum Proteins","year":2015,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Per- and polyfluoroalkyl substances research","field":"Environmental Science","cited_by":221,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates - Health Solutions","keywords":"Chemistry; Human serum albumin; Blood proteins; Ultrafiltration (renal); Dissociation constant; Structural isomer; Chromatography; Serum albumin; Biochemistry; Stereochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001124651,0.0003220801,0.0003505026,0.0005638796,0.0004559865,0.00006026142,0.001314744,0.0001930104,0.001323987],"category_scores_gemma":[0.00008133701,0.0002965153,0.000051327,0.002252956,0.004688709,0.0006818495,0.001766862,0.0003833743,0.0009734697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008520276,"about_ca_system_score_gemma":0.00005550671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008557014,"about_ca_topic_score_gemma":0.00005448195,"domain_scores_codex":[0.9961153,0.00006042165,0.0004110442,0.001043024,0.001291348,0.001078883],"domain_scores_gemma":[0.9984869,0.00003121182,0.0001365635,0.0007226622,0.00001124242,0.0006114262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005006267,0.0001545378,0.1274807,0.000004209944,0.000004819334,0.00001987572,0.0009403873,0.000144535,0.7579572,0.0001892486,0.0002478991,0.1128066],"study_design_scores_gemma":[0.001174054,0.001519825,0.1215818,0.00004660644,0.00001295563,0.000163426,0.005229159,0.0004969254,0.782546,0.001153972,0.08515572,0.0009195813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914042,0.001642055,0.0001091888,0.001001173,0.0001344628,0.0006604414,0.00005347279,0.0001056457,0.004889383],"genre_scores_gemma":[0.9960904,0.0003432198,0.002619982,0.00006970029,0.0000232607,0.00007649607,0.000002979301,0.00002484133,0.0007491859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.111887,"threshold_uncertainty_score":0.9999487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02005941640051298,"score_gpt":0.2497162929662878,"score_spread":0.2296568765657748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}