{"id":"W1970029396","doi":"10.1016/j.jphotobiol.2008.04.005","title":"Complement activation cascade and its regulation: Relevance for the response of solid tumors to photodynamic therapy","year":2008,"lang":"en","type":"article","venue":"Journal of Photochemistry and Photobiology B Biology","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute","keywords":"Decay-accelerating factor; Complement system; Complement control protein; Photodynamic therapy; Antibody; Regulator; Cancer research; Photosensitizer; Immunology; Alternative complement pathway; Factor H; Biology; Chemistry; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004199987,0.000248551,0.0002133159,0.0005291725,0.0003127825,0.0006719384,0.0002767903,0.0005764499,0.001462136],"category_scores_gemma":[0.0005496541,0.00008962095,0.0001616612,0.000441226,0.0006664937,0.0004262097,0.0002541722,0.0006002552,0.0001421846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006749578,"about_ca_system_score_gemma":0.0006663949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001423936,"about_ca_topic_score_gemma":0.0007781576,"domain_scores_codex":[0.9998468,0.00005552479,0.00001063052,0.00001688912,0.00002954701,0.00004058203],"domain_scores_gemma":[0.9998279,0.00006157222,0.00004200611,0.000009899936,0.0000321734,0.00002646078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006629989,0.0004150294,0.008230678,0.0007635009,0.00006866837,0.001195149,0.0002856738,0.001201507,0.8624312,0.02263193,0.001505818,0.09464079],"study_design_scores_gemma":[0.0007976205,0.003767052,0.2089593,0.0003508645,0.0004369745,0.007478545,0.0009008717,0.01729832,0.6790057,0.03877111,0.04212501,0.000108695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8653184,0.1118509,0.005718202,0.003468885,0.0002686506,0.0001121237,0.000225655,0.00005031905,0.01298684],"genre_scores_gemma":[0.9832206,0.01373293,0.001225493,0.0001351129,0.0001745808,0.00002523551,0.00006733611,0.000003526252,0.001415341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001462136,"threshold_uncertainty_score":0.004897237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03738144044960459,"score_gpt":0.3587363629236837,"score_spread":0.321354922474079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}