{"id":"W1970031380","doi":"10.1124/jpet.102.044073","title":"Structural Requirements for Functional Interaction of Glutathione Tripeptide Analogs with the Human Multidrug Resistance Protein 1 (MRP1)","year":2003,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Tripeptide; Glutathione; Chemistry; Biochemistry; Stereochemistry; Amino acid; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003484852,0.0003783292,0.0003899537,0.00015241,0.0003843293,0.0005284962,0.0003798708,0.0006581154,0.003286927],"category_scores_gemma":[0.000601953,0.0002521466,0.0003543458,0.0001178016,0.0003607215,0.0003463903,0.000321469,0.000732131,0.0007530313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004113968,"about_ca_system_score_gemma":0.0002664395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005868092,"about_ca_topic_score_gemma":0.0007312762,"domain_scores_codex":[0.9997218,0.0001061179,0.00002905576,0.00003185869,0.00005827127,0.00005285121],"domain_scores_gemma":[0.9996055,0.0001711804,0.00009359622,0.00002116838,0.00004126094,0.00006746119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006296835,0.0001162031,0.0005374665,0.00005609402,0.00002005279,0.0006256848,0.00004770696,0.001089462,0.9943612,0.001115935,0.0001357823,0.001264746],"study_design_scores_gemma":[0.0001177201,0.0006383598,0.002868719,0.000013042,0.00004356975,0.001521413,0.0001204882,0.004871857,0.9867381,0.0002787356,0.002760749,0.00002729072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972728,0.0004068959,0.001180422,0.0001339369,0.00002369695,0.00001907977,0.00009037644,0.00003136624,0.0008414179],"genre_scores_gemma":[0.9983951,0.0001173392,0.0007787626,0.00004739936,0.000007538986,0.00001115778,0.0002214808,0.00001427258,0.0004069675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003286927,"threshold_uncertainty_score":0.01099586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04729002877588157,"score_gpt":0.3550379672376085,"score_spread":0.3077479384617269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}