{"id":"W1970041220","doi":"10.1016/j.immuni.2014.12.030","title":"The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo","year":2015,"lang":"en","type":"article","venue":"Immunity","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":659,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal General Hospital; McGill University; McGill University Health Centre","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"AMPK; Cell biology; Biology; Bioenergetics; Effector; T cell; Protein kinase A; Mitochondrion; Kinase; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002045455,0.000309361,0.0003424599,0.0003085368,0.0002306765,0.0009620581,0.0002012306,0.0003404821,0.002337956],"category_scores_gemma":[0.0002026437,0.0002694234,0.0002584087,0.0002146385,0.0003561109,0.0006347558,0.0003746931,0.0009914231,0.0006300681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003739074,"about_ca_system_score_gemma":0.0001716012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001451734,"about_ca_topic_score_gemma":0.0003335979,"domain_scores_codex":[0.999798,0.00004037395,0.00001195282,0.00005900557,0.00002696417,0.00006382111],"domain_scores_gemma":[0.9998705,0.00001816281,0.00003554582,0.00002386176,0.00001266113,0.00003926647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002335508,0.00007543268,0.001188732,0.0000536105,0.00001856743,0.00005260809,0.00001773963,0.0002202842,0.9905573,0.0007565443,0.0002305101,0.004493235],"study_design_scores_gemma":[0.0001903038,0.0007039694,0.03989826,0.00003142879,0.00007986698,0.0003704596,0.0001783169,0.003501577,0.9463605,0.002534212,0.006121299,0.00002976033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839071,0.005810626,0.004958852,0.001037318,0.000280796,0.00001870327,0.0005208527,0.0001293199,0.003336504],"genre_scores_gemma":[0.9951478,0.001486534,0.0009762176,0.0001962147,0.00005345342,0.00001641716,0.0002633025,0.00004245339,0.001817524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002337956,"threshold_uncertainty_score":0.007821262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01745271822672139,"score_gpt":0.2426931996133068,"score_spread":0.2252404813865855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}