{"id":"W1970069874","doi":"10.1158/0008-5472.sabcs-09-4056","title":"Prognostic and Predictive Impact of Intrinsic Biological Classification by Immunohistochemistry (IHC) and QPCR for Adjuvant Tamoxifen in Pre-Menopausal Breast Cancer: Results from the NCIC CTG MA.12 Trial.","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; University of British Columbia; Ontario Institute for Cancer Research; BC Cancer Agency","funders":"","keywords":"Breast cancer; Medicine; Tamoxifen; Oncology; Immunohistochemistry; Internal medicine; Subtyping; Population; Estrogen receptor; Biomarker; Tissue microarray; Cancer; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003044131,0.0006077118,0.0009373257,0.000248939,0.0001910302,0.0006676707,0.0004650829,0.0007836635,0.001161032],"category_scores_gemma":[0.00333969,0.000210799,0.0006701985,0.0003186715,0.0004306431,0.0004004908,0.0002794536,0.0008738138,0.0001809308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004234544,"about_ca_system_score_gemma":0.0004354093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001093471,"about_ca_topic_score_gemma":0.002768067,"domain_scores_codex":[0.9992636,0.0004276593,0.00003657732,0.0001132454,0.00009880323,0.00006023384],"domain_scores_gemma":[0.9979437,0.0009113647,0.0004351794,0.0001716405,0.000168891,0.000369234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5389242,0.001402113,0.373611,0.000794603,0.004413899,0.0001927903,0.0002068822,0.001555045,0.01377006,0.000114949,0.003162701,0.06185198],"study_design_scores_gemma":[0.04806526,0.04451754,0.8892065,0.0002045529,0.00698583,0.0004298271,0.0001194408,0.004435116,0.00304767,0.0003684221,0.002543698,0.00007602812],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995624,0.00273528,0.0001422192,0.0001927922,0.0000289437,0.0001134928,0.000715393,0.00001058934,0.000437267],"genre_scores_gemma":[0.996747,0.0004164864,0.0002634512,0.0001586396,0.00008876553,0.0002031425,0.001812952,0.000004909852,0.0003046943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003044131,"threshold_uncertainty_score":0.0160991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04702133200026477,"score_gpt":0.3863652711130364,"score_spread":0.3393439391127717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}