{"id":"W1970075541","doi":"10.1021/ml200093v","title":"Crucial Role of 3-Bromoethyl in Removing the Estrogenic Activity of 17β-HSD1 Inhibitor 16β-(<i>m</i>-Carbamoylbenzyl)estradiol","year":2011,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"","keywords":"Estrone; In vivo; Estrogen; Pharmacology; Pharmacokinetics; Chemistry; Side chain; Steroid; In vitro; Internal medicine; Biochemistry; Medicine; Biology; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000340858,0.0002404406,0.0003158301,0.00003452445,0.0000457637,0.000004255272,0.0004092216,0.0002817952,0.00001783641],"category_scores_gemma":[0.0001110887,0.0001894445,0.0001652067,0.0001690818,0.0004098817,0.000008175737,0.0001129045,0.0004175432,0.000001308924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002768337,"about_ca_system_score_gemma":0.0001124659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002363056,"about_ca_topic_score_gemma":0.000006102953,"domain_scores_codex":[0.998564,0.00008709056,0.0003801847,0.0003513887,0.0002768223,0.0003404942],"domain_scores_gemma":[0.9990611,0.00004297495,0.0002688488,0.0004793121,0.00004595278,0.0001018232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002625535,0.0001048106,0.004183333,0.00008839862,0.0001239714,0.00002495422,0.0004275856,0.000009993761,0.9930759,0.000004408756,0.0001485004,0.001545601],"study_design_scores_gemma":[0.0007312191,0.0001403336,0.004216906,0.0001034462,0.00008880754,0.00006911607,0.0002383639,0.00001721314,0.9941065,0.0000212346,0.00009229613,0.0001745927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967128,0.001717619,0.00002451566,0.0001730565,0.0001010705,0.0001762836,0.000009444039,0.000009210228,0.001075969],"genre_scores_gemma":[0.9993494,0.00008037904,0.0001132939,0.0001138516,0.0002642945,0.00001450745,0.00001902302,0.00002642477,0.00001884981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002636544,"threshold_uncertainty_score":0.7725324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007052863860610805,"score_gpt":0.2026284512825652,"score_spread":0.1955755874219544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}