{"id":"W1970075541","doi":"10.1021/ml200093v","title":"Crucial Role of 3-Bromoethyl in Removing the Estrogenic Activity of 17β-HSD1 Inhibitor 16β-(<i>m</i>-Carbamoylbenzyl)estradiol","year":2011,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"","keywords":"Estrone; In vivo; Estrogen; Pharmacology; Pharmacokinetics; Chemistry; Side chain; Steroid; In vitro; Internal medicine; Biochemistry; Medicine; Biology; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001262555,0.0002164495,0.0002390524,0.00005855122,0.00007235521,0.0001424506,0.0002238567,0.0002244802,0.000794735],"category_scores_gemma":[0.0001730173,0.0001012596,0.0001459033,0.00006639258,0.0001562059,0.0001673471,0.0001160929,0.0002402327,0.0002648419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001071497,"about_ca_system_score_gemma":0.000184323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004308958,"about_ca_topic_score_gemma":0.0005325328,"domain_scores_codex":[0.9999317,0.000017501,0.000004334272,0.00001067705,0.00001459391,0.00002128841],"domain_scores_gemma":[0.9999224,0.00002491675,0.00002008757,0.00000794552,0.00001095521,0.00001357434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002864484,0.00001906902,0.0001312549,0.00004831402,0.000006017827,0.00005766004,0.00001109526,0.0001152814,0.9969531,0.0001144049,0.00002213965,0.002235209],"study_design_scores_gemma":[0.00001942933,0.0003950096,0.0008694204,0.000003241725,0.00001035314,0.0001719454,0.000005984007,0.0002337483,0.9967775,0.00002961551,0.001480105,0.000003677878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892986,0.005089714,0.002578753,0.00007623679,0.00002448475,0.00002431795,0.0001090442,0.00004357579,0.002755185],"genre_scores_gemma":[0.9950359,0.001833347,0.001691496,0.00006238544,0.000009827564,0.00001418055,0.0001156311,0.00001315185,0.001224002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000794735,"threshold_uncertainty_score":0.002658665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007052863860610805,"score_gpt":0.2026284512825652,"score_spread":0.1955755874219544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}