{"id":"W1970081438","doi":"10.1124/mol.112.078352","title":"Carbonylation Induces Heterogeneity in Cardiac Ryanodine Receptor Function in Diabetes Mellitus","year":2012,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; University of Calgary","keywords":"Ryanodine receptor; Internal medicine; Endocrinology; Chemistry; Ryanodine receptor 2; Endoplasmic reticulum; Methylglyoxal; Myocyte; Biochemistry; Biology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003848466,0.0002132705,0.0003457572,0.0002670764,0.0002144571,0.0002565442,0.0002014414,0.0002977441,0.001324669],"category_scores_gemma":[0.0003336288,0.0002236726,0.0003631409,0.000206223,0.0002186757,0.0003122084,0.0003340237,0.0005700956,0.0001840069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002299952,"about_ca_system_score_gemma":0.00009481033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002592215,"about_ca_topic_score_gemma":0.0002644271,"domain_scores_codex":[0.9998091,0.00004453505,0.00002808416,0.000042401,0.00002781465,0.0000480447],"domain_scores_gemma":[0.9996917,0.00004606102,0.0001133796,0.0000489001,0.00002632047,0.00007362312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002077104,0.00006841454,0.001813485,0.00002095969,0.00003562752,0.0001840361,0.00003388975,0.00003320869,0.9945471,0.0001260946,0.00004367437,0.001016314],"study_design_scores_gemma":[0.0002985717,0.001634612,0.182801,0.00001531466,0.0001795945,0.002134489,0.0002221786,0.001321305,0.8093842,0.0006742751,0.001307198,0.00002743562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986328,0.0003970133,0.0004908832,0.00006680714,0.00002139392,0.000006572378,0.00006510515,0.00001013248,0.0003092506],"genre_scores_gemma":[0.9989595,0.0002187034,0.0002709082,0.00005981065,0.00002360094,0.000009838616,0.0001354635,0.0000116429,0.0003105694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001324669,"threshold_uncertainty_score":0.004431486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0163623254863862,"score_gpt":0.3159802105255379,"score_spread":0.2996178850391517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}