{"id":"W1970087902","doi":"10.1016/j.cellsig.2009.09.038","title":"Neu1 desialylation of sialyl α-2,3-linked β-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling","year":2009,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":190,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Ectodomain; Receptor; Toll-like receptor; Chemistry; TLR4; Sialidase; HEK 293 cells; Cell biology; Biochemistry; Neuraminidase; Molecular biology; Biology; Innate immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004714114,0.0002426111,0.000524101,0.000183255,0.0001847737,0.00001490664,0.0001712751,0.0004546304,0.0004265224],"category_scores_gemma":[0.00007015999,0.0002419109,0.0001766049,0.0001791021,0.0001495917,0.0001190664,0.00002664273,0.0002052716,0.000007215451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003513828,"about_ca_system_score_gemma":0.00008154695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004130502,"about_ca_topic_score_gemma":0.000002879714,"domain_scores_codex":[0.9983082,0.0001745222,0.0006700571,0.000440263,0.00006949269,0.0003374981],"domain_scores_gemma":[0.9987395,0.0002404125,0.0005377418,0.0002064069,0.0002438013,0.00003214625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007171986,0.00009551263,0.0003712266,0.00008883965,0.0001268813,2.443843e-7,0.0007831942,0.00008850393,0.9936688,0.0003677018,0.0002865313,0.003405366],"study_design_scores_gemma":[0.001227638,0.0006079829,0.0001517482,0.0001167956,0.0001021837,0.000001238052,0.00020706,0.0001003558,0.9940785,0.0005867172,0.002591038,0.000228773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9314748,0.002376439,0.06490323,0.0001718955,0.0004396175,0.0004946378,0.00002953844,0.00003824638,0.00007161283],"genre_scores_gemma":[0.9971882,0.000131244,0.001787874,0.00007409669,0.0001688466,0.00001541262,0.0003482644,0.00002453137,0.0002614962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06571345,"threshold_uncertainty_score":0.9864839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01421731131569403,"score_gpt":0.2324764537897753,"score_spread":0.2182591424740812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}