{"id":"W1970087902","doi":"10.1016/j.cellsig.2009.09.038","title":"Neu1 desialylation of sialyl α-2,3-linked β-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling","year":2009,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":190,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Ectodomain; Receptor; Toll-like receptor; Chemistry; TLR4; Sialidase; HEK 293 cells; Cell biology; Biochemistry; Neuraminidase; Molecular biology; Biology; Innate immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002234149,0.0004534078,0.0002154928,0.0001622723,0.0002076408,0.000560053,0.0002009112,0.000265826,0.001195898],"category_scores_gemma":[0.0002957385,0.0002338661,0.0003135088,0.0001348821,0.0002552117,0.00040477,0.0004151384,0.0006525531,0.0008717439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007499812,"about_ca_system_score_gemma":0.0003611288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007718315,"about_ca_topic_score_gemma":0.0008609019,"domain_scores_codex":[0.9998147,0.00004270161,0.00001405308,0.00002623437,0.0000398753,0.00006245436],"domain_scores_gemma":[0.9998203,0.0000238732,0.00004896057,0.00002928698,0.00002880026,0.00004873319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001688926,0.0000120907,0.0003530097,0.00002414972,0.000004646599,0.00006529465,0.00001326772,0.00008108695,0.9976246,0.0003479653,0.00005555105,0.001249459],"study_design_scores_gemma":[0.000005747729,0.00003862254,0.0032263,0.000003049293,0.000005716777,0.0002663903,0.00002430345,0.0006061116,0.9937265,0.0001133395,0.001979964,0.000003898072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914129,0.001553051,0.00441735,0.0002249272,0.00004001332,0.00002010828,0.0003368227,0.00009919139,0.001895681],"genre_scores_gemma":[0.9933294,0.0005456437,0.001591982,0.00005862515,0.00000859274,0.0000108048,0.0009179354,0.00003601936,0.003500975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001195898,"threshold_uncertainty_score":0.005441487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01421731131569403,"score_gpt":0.2324764537897753,"score_spread":0.2182591424740812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}