{"id":"W1970104094","doi":"10.1371/journal.pone.0064787","title":"Th Cells Promote CTL Survival and Memory via Acquired pMHC-I and Endogenous IL-2 and CD40L Signaling and by Modulating Apoptosis-Controlling Pathways","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Saskatchewan Cancer Agency","funders":"Canadian Institutes of Health Research; University of Saskatchewan","keywords":"CTL*; Cytotoxic T cell; Biology; Adoptive cell transfer; CD8; CD40; Cell biology; Immunology; Flow cytometry; T cell; Cancer research; Immune system; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001089114,0.0005303146,0.0001622562,0.0001798796,0.00008008305,0.000236929,0.0001227221,0.0001899661,0.001748209],"category_scores_gemma":[0.00005651313,0.00009460983,0.0002044297,0.0000603351,0.0001617007,0.0001673045,0.0002069005,0.0005650775,0.0003909376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001598302,"about_ca_system_score_gemma":0.0001739567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001004183,"about_ca_topic_score_gemma":0.0001973897,"domain_scores_codex":[0.9998702,0.00001641212,0.000007939274,0.00002166298,0.00002780848,0.00005599634],"domain_scores_gemma":[0.9999241,0.000008082041,0.00002553511,0.000007848907,0.000009280026,0.00002520356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001147986,0.00003919967,0.0005423217,0.00004530192,0.000004655393,0.00006281473,0.0000127059,0.00006225053,0.9974235,0.00008197947,0.00003272514,0.001577846],"study_design_scores_gemma":[0.00004200813,0.0007262512,0.00443484,0.00001139108,0.00003132778,0.0002816638,0.00003167419,0.0006220421,0.9913845,0.00009771561,0.002334245,0.000002409786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948727,0.001075441,0.002238151,0.00006118136,0.00002699527,0.0000238144,0.0001314756,0.00009318836,0.001477052],"genre_scores_gemma":[0.9950221,0.0006281162,0.001492126,0.00003306934,0.00002710284,0.0000286431,0.0002067065,0.00001169442,0.002550593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001748209,"threshold_uncertainty_score":0.005848348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02663223365805615,"score_gpt":0.1795193162630951,"score_spread":0.152887082605039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}