{"id":"W1970114393","doi":"10.1016/j.freeradbiomed.2015.01.005","title":"Buthionine sulfoximine, an inhibitor of glutathione biosynthesis, induces expression of soluble epoxide hydrolase and markers of cellular hypertrophy in a rat cardiomyoblast cell line: Roles of the NF-κB and MAPK signaling pathways","year":2015,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"MAPK/ERK pathway; Downregulation and upregulation; Kinase; Signal transduction; p38 mitogen-activated protein kinases; Buthionine sulfoximine; MEK inhibitor; Protein kinase A; Chemistry; Western blot; Molecular biology; Biology; Cell biology; Glutathione; Internal medicine; Biochemistry; Medicine; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002024153,0.0006448606,0.0004442635,0.0003198418,0.0001816892,0.0001832589,0.0002003905,0.0002455171,0.00122495],"category_scores_gemma":[0.0001004994,0.0002256824,0.0003924664,0.0002995981,0.0003587416,0.0002392813,0.0001474959,0.0006209976,0.0002096465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002929081,"about_ca_system_score_gemma":0.000419896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001047935,"about_ca_topic_score_gemma":0.002313698,"domain_scores_codex":[0.9998723,0.00001865976,0.00001659824,0.00002299506,0.00002962677,0.00003970009],"domain_scores_gemma":[0.9998554,0.00003146715,0.00003618708,0.00002055828,0.00001090879,0.0000453225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002306972,0.00003333892,0.00006375931,0.00001418448,0.000004255397,0.00004280962,0.000007049511,0.00001336161,0.9993398,0.00002565356,0.00001388366,0.0002111462],"study_design_scores_gemma":[0.00003065273,0.0004954342,0.00181071,0.000001570468,0.00001583159,0.00008549594,0.00001554894,0.0001788134,0.9969577,0.00001817786,0.0003882132,0.00000192186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938329,0.00156999,0.002859615,0.0001775745,0.00007737682,0.0000492814,0.0003796639,0.00009844036,0.0009551732],"genre_scores_gemma":[0.9914055,0.001683378,0.002801951,0.00007495491,0.00003098629,0.00006758089,0.00104549,0.00002574696,0.002864447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00122495,"threshold_uncertainty_score":0.004097939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0158706353556797,"score_gpt":0.2398187185027907,"score_spread":0.223948083147111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}