{"id":"W1970130845","doi":"10.1016/j.cub.2013.09.049","title":"Mutation, Condition, and the Maintenance of Extended Lifespan in Drosophila","year":2013,"lang":"en","type":"article","venue":"Current Biology","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Longevity; Drosophila melanogaster; Fecundity; Drosophila (subgenus); Senescence; Mutation Accumulation; Natural selection; Pleiotropy; Genetics; Evolutionary biology; Population; Mutation rate; Demography; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001229894,0.0002410928,0.0001878682,0.0005618899,0.0001699683,0.0002661899,0.0002384878,0.000302357,0.0007761117],"category_scores_gemma":[0.000192489,0.0001344266,0.0001474254,0.0001501551,0.0004106446,0.0003053414,0.0002808242,0.0003228,0.0000925033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002857922,"about_ca_system_score_gemma":0.0002020433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000632563,"about_ca_topic_score_gemma":0.001243878,"domain_scores_codex":[0.9999248,0.00001201583,0.00001267571,0.00001647848,0.00002395872,0.00001012558],"domain_scores_gemma":[0.999806,0.00003590202,0.00007959251,0.00002230504,0.00001327486,0.0000429634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003577719,0.00002624023,0.001440983,0.00004920368,0.00001416192,0.000464237,0.00003521472,0.0002474082,0.9903341,0.001387194,0.0001278399,0.00551564],"study_design_scores_gemma":[0.0001560132,0.0007094108,0.1270785,0.00004905725,0.0001522905,0.004462415,0.000173556,0.005782248,0.8501455,0.003156183,0.008060455,0.00007442538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956096,0.001678274,0.001254465,0.00007969061,0.00001471431,0.000004168849,0.0002029194,0.00004785517,0.001108425],"genre_scores_gemma":[0.9965766,0.0007965775,0.001026964,0.00003895614,0.000009119159,0.000007962797,0.0001850182,0.00002196557,0.001336777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007761117,"threshold_uncertainty_score":0.002596378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009229565887286073,"score_gpt":0.2593340361126923,"score_spread":0.2501044702254063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}