{"id":"W1970173052","doi":"10.1038/icb.2010.21","title":"COMBODY: one‐domain antibody multimer with improved avidity","year":2010,"lang":"en","type":"article","venue":"Immunology and Cell Biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Institute for Biological Sciences","funders":"","keywords":"Avidity; Single-domain antibody; Antibody; Peptide; Chemistry; In vitro; T-cell receptor; Computational biology; Molecular biology; Cell biology; T cell; Biology; Immune system; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001893028,0.0001773233,0.0003728604,0.00008793763,0.0001694741,0.000007306054,0.0001205116,0.0003627144,0.0005998314],"category_scores_gemma":[0.00002446569,0.0001190887,0.00005226371,0.00008132328,0.001150892,0.00003053476,0.0001153534,0.0008557717,0.000110974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006317207,"about_ca_system_score_gemma":0.00008013553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003648357,"about_ca_topic_score_gemma":0.00008787389,"domain_scores_codex":[0.9988952,0.00009136546,0.0001792216,0.0003412706,0.00005602785,0.0004369107],"domain_scores_gemma":[0.999321,0.0001457133,0.00005819184,0.0002759979,0.00008549318,0.0001135529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001276538,0.0002408746,0.07407612,0.00002840972,0.0001480393,0.0000291321,0.00007878601,1.494896e-8,0.9172751,0.001746769,0.00004328593,0.005056916],"study_design_scores_gemma":[0.007252299,0.005087151,0.4690133,0.00003175318,0.0001250835,0.00072597,0.0001944374,0.0001279125,0.3416522,0.001848786,0.1734093,0.0005318085],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878855,0.0009316616,0.00006817558,0.002014275,0.0002192565,0.0002561233,0.00001895754,0.0000411223,0.008564929],"genre_scores_gemma":[0.9944196,0.0004705235,0.002188179,0.0004841366,0.00012634,0.0000168963,0.0001567303,0.00001411353,0.002123477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.575623,"threshold_uncertainty_score":0.6567733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01200001171101563,"score_gpt":0.2926366514586511,"score_spread":0.2806366397476355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}