{"id":"W1970173052","doi":"10.1038/icb.2010.21","title":"COMBODY: one‐domain antibody multimer with improved avidity","year":2010,"lang":"en","type":"article","venue":"Immunology and Cell Biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Institute for Biological Sciences","funders":"","keywords":"Avidity; Single-domain antibody; Antibody; Peptide; Chemistry; In vitro; T-cell receptor; Computational biology; Molecular biology; Cell biology; T cell; Biology; Immune system; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002697431,0.0005220504,0.0002931684,0.0003243697,0.0001241981,0.0003361808,0.0003733941,0.0004040756,0.001443957],"category_scores_gemma":[0.0001703564,0.0001554075,0.0002275366,0.000165865,0.0001893572,0.000373883,0.0003323773,0.0006539075,0.0005119433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003024202,"about_ca_system_score_gemma":0.0001166866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001517503,"about_ca_topic_score_gemma":0.0002097391,"domain_scores_codex":[0.9998815,0.00002401098,0.000008567078,0.00002943026,0.00003242572,0.00002398461],"domain_scores_gemma":[0.9998952,0.0000195659,0.00002661051,0.00001383271,0.0000161422,0.00002872309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008157198,0.00004543179,0.0001746822,0.00003937471,0.000009238385,0.00005055625,0.000009691509,0.0001692972,0.992831,0.0002982451,0.0002021673,0.006088709],"study_design_scores_gemma":[0.0000535498,0.0003631001,0.0007449186,0.000003889567,0.00002147348,0.0004590173,0.000004618609,0.002478293,0.9885567,0.00007373027,0.00723289,0.00000772418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9430603,0.00403539,0.04705339,0.0002729173,0.0001035943,0.0001532539,0.0003465563,0.0006639311,0.004310705],"genre_scores_gemma":[0.9518974,0.00112531,0.04049246,0.0002278836,0.00004378653,0.0001232309,0.0006725788,0.000077442,0.00533997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001443957,"threshold_uncertainty_score":0.00483048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01200001171101563,"score_gpt":0.2926366514586511,"score_spread":0.2806366397476355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}