{"id":"W1970217517","doi":"10.1021/jm200010x","title":"Quercetin Diacylglycoside Analogues Showing Dual Inhibition of DNA Gyrase and Topoisomerase IV as Novel Antibacterial Agents","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; University of Guelph","keywords":"DNA gyrase; Topoisomerase IV; Staphylococcus aureus; Chemistry; Microbiology; Antibacterial activity; Escherichia coli; DNA supercoil; Antibacterial agent; Antibiotics; Bacteria; Biochemistry; DNA; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001147834,0.0003280015,0.0002654,0.0002372934,0.0000704511,0.0002125351,0.0003337061,0.0002504065,0.0005509497],"category_scores_gemma":[0.00007954744,0.0001248681,0.0001825811,0.0001631704,0.0001200378,0.0001483748,0.0001431725,0.0003405503,0.0001704105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003031933,"about_ca_system_score_gemma":0.0001732178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004837953,"about_ca_topic_score_gemma":0.001250031,"domain_scores_codex":[0.9999361,0.0000139593,0.000004247071,0.0000129644,0.00001547942,0.00001712399],"domain_scores_gemma":[0.9999704,0.00000273971,0.000009123584,0.000002043812,0.000007235103,0.000008284524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001583057,0.00008660852,0.0001481674,0.0000970507,0.00001544814,0.000112072,0.00001617609,0.001332658,0.9892119,0.0005479371,0.00008742693,0.008186335],"study_design_scores_gemma":[0.0002651761,0.003094824,0.001850273,0.00002431471,0.00009723249,0.0004347214,0.0000277374,0.003687651,0.976817,0.0002223607,0.01345204,0.00002668531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733539,0.009001062,0.01239823,0.0002506962,0.00006112763,0.0002682722,0.0002942117,0.0001114222,0.004261129],"genre_scores_gemma":[0.9843813,0.003919192,0.009149659,0.0001248074,0.00001360792,0.00007072552,0.0003770062,0.00001169699,0.001952034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005509497,"threshold_uncertainty_score":0.002199829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02809461427334288,"score_gpt":0.261531607458208,"score_spread":0.2334369931848652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}