{"id":"W1970226848","doi":"10.1038/onc.2012.127","title":"Egr-1 mediates epidermal growth factor-induced downregulation of E-cadherin expression via Slug in human ovarian cancer cells","year":2012,"lang":"en","type":"article","venue":"Oncogene","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":false,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Downregulation and upregulation; Biology; Epidermal growth factor; Cell biology; Small interfering RNA; MAPK/ERK pathway; Chromatin immunoprecipitation; Cancer research; Slug; Signal transduction; Protein kinase B; PI3K/AKT/mTOR pathway; Cadherin; Transfection; Cell culture; Cell; Gene expression; Gene; Promoter; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001654334,0.0002658493,0.0002933793,0.0002881621,0.000199163,0.0003284668,0.000201881,0.000200582,0.001155319],"category_scores_gemma":[0.0001288913,0.0001813169,0.0003457666,0.0002836331,0.0002125205,0.0002259679,0.0001943778,0.000424157,0.0004103301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003498471,"about_ca_system_score_gemma":0.0003390357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003213616,"about_ca_topic_score_gemma":0.003042359,"domain_scores_codex":[0.999871,0.00002936855,0.00001179093,0.00001108329,0.00001914955,0.00005752068],"domain_scores_gemma":[0.9999639,0.000008988831,0.000006203343,0.000007842965,0.00000507156,0.000007956542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003775354,0.00008567259,0.0006694745,0.00007972734,0.00001367788,0.0002290667,0.00008680341,0.0001092534,0.9964314,0.0002382544,0.000179982,0.001499298],"study_design_scores_gemma":[0.00005603634,0.0003075486,0.01579049,0.00000668481,0.00003430372,0.000317744,0.0001244909,0.001569063,0.9787295,0.00005923468,0.002998827,0.000005977864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969049,0.0009947162,0.0005130329,0.00008111195,0.00001581981,0.00002591036,0.000288289,0.00003899455,0.001137154],"genre_scores_gemma":[0.9962795,0.0007656962,0.0004632215,0.00005316429,0.000006248577,0.00003343495,0.0007568398,0.000008003936,0.001633695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003213616,"threshold_uncertainty_score":0.006389797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03970906457226177,"score_gpt":0.3152248449835023,"score_spread":0.2755157804112406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}