{"id":"W1970244138","doi":"10.1593/tlo.12307","title":"Imatinib and Dasatinib Inhibit Hemangiosarcoma and Implicate PDGFR-β and Src in Tumor Growth","year":2013,"lang":"en","type":"article","venue":"Translational Oncology","topic":"Veterinary Oncology Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Center for Advancing Translational Sciences","keywords":"Dasatinib; Hemangiosarcoma; Imatinib; Cancer research; Tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; Medicine; Platelet-derived growth factor receptor; Doxorubicin; Angiosarcoma; Pharmacology; Tyrosine-kinase inhibitor; Imatinib mesylate; Pathology; Internal medicine; Cancer; Receptor; Growth factor; Chemotherapy; Myeloid leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001901849,0.0002100945,0.0002994039,0.000195025,0.00009902583,0.0001702644,0.0001212505,0.0002580062,0.0009367539],"category_scores_gemma":[0.0001568591,0.0001121698,0.0002296481,0.0001196642,0.0002177059,0.0002077428,0.000165242,0.0004942307,0.000287429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001761553,"about_ca_system_score_gemma":0.0002063229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002082805,"about_ca_topic_score_gemma":0.0008004694,"domain_scores_codex":[0.9997994,0.0000376419,0.00002756997,0.00003016307,0.00006956704,0.00003559346],"domain_scores_gemma":[0.9999108,0.00001850301,0.00003114392,0.000008809914,0.00001173557,0.00001903237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005562457,0.0001629422,0.001094166,0.00008930796,0.00001732052,0.0001196823,0.00002482368,0.0003752677,0.98618,0.0003312349,0.0001759535,0.01087306],"study_design_scores_gemma":[0.0001807072,0.003500036,0.02193536,0.000007067104,0.00003297486,0.002350409,0.00007190484,0.00274971,0.9610819,0.0003073215,0.007770939,0.00001172104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911755,0.002715235,0.002377766,0.0002158632,0.00004897034,0.00007026347,0.000250479,0.00004916538,0.003096661],"genre_scores_gemma":[0.9951087,0.001078791,0.001981008,0.00006203556,0.000008823367,0.00005412034,0.0003281515,0.000006627963,0.001371831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009367539,"threshold_uncertainty_score":0.003133714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03544258671563995,"score_gpt":0.3490581320182304,"score_spread":0.3136155453025904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}