{"id":"W1970247177","doi":"10.1074/jbc.m414229200","title":"Functional Analyses of Oxygenases in Jadomycin Biosynthesis and Identification of JadH as a Bifunctional Oxygenase/Dehydrase","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Cancer Institute; National Institutes of Health; Chinese Academy of Sciences","keywords":"Polyketide; Oxygenase; Biochemistry; Streptomyces; Polyketide synthase; Mutant; Chemistry; Heterologous expression; Aglycone; Biosynthesis; ATP synthase; Streptomycetaceae; Biology; Stereochemistry; Actinomycetales; Gene; Genetics; Recombinant DNA; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000468411,0.0001287066,0.0004519673,0.0001011623,0.00002323977,0.000006607616,0.00007924017,0.000172785,0.0006913135],"category_scores_gemma":[0.001295612,0.00007960708,0.0001867333,0.0002477966,0.0001921956,0.00007322726,0.00002814558,0.000202435,0.000002695338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004795479,"about_ca_system_score_gemma":0.00008955607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001206253,"about_ca_topic_score_gemma":9.860864e-7,"domain_scores_codex":[0.9985701,0.00003869462,0.0008586003,0.000183533,0.0002302987,0.0001187039],"domain_scores_gemma":[0.9986812,0.0001965422,0.0006131328,0.0001167897,0.0002972637,0.00009500281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009387582,0.0004079893,0.003693347,0.0001011824,0.0001041851,0.00001113791,0.00001173233,0.00001705978,0.9904609,0.000006699184,0.0003666175,0.003880375],"study_design_scores_gemma":[0.0005880112,0.0001633473,0.0645619,0.0001366671,0.00008994849,0.0002618063,0.00009528547,0.00002774223,0.933586,0.00004374879,0.0003704622,0.00007510214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959474,0.002250484,0.00001975302,0.001550156,0.00003435613,0.00006253333,0.00002778209,0.000004344909,0.0001031584],"genre_scores_gemma":[0.9982365,0.000601349,0.0005788326,0.00008685202,0.0003150423,3.787557e-7,0.00001347536,0.000004778838,0.0001628232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06086856,"threshold_uncertainty_score":0.7569398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0447851080517568,"score_gpt":0.2957603306627086,"score_spread":0.2509752226109518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}