{"id":"W1970256087","doi":"10.1371/journal.pone.0034055","title":"RNA Sensors Enable Human Mast Cell Anti-Viral Chemokine Production and IFN-Mediated Protection in Response to Antibody-Enhanced Dengue Virus Infection","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Dengue virus; Dengue fever; Biology; CXCL10; Chemokine; Virology; Antibody-dependent enhancement; Interferon; Immune system; Innate immune system; Virus; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005269579,0.000176776,0.0002801681,0.0002981026,0.0002008124,0.00001454548,0.00004541145,0.000216407,0.0002753788],"category_scores_gemma":[0.0002220028,0.0001805697,0.00002493523,0.0002731118,0.00007205189,0.0001857683,0.00004941086,0.0003314324,0.0003369789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008453629,"about_ca_system_score_gemma":0.00001566669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007449691,"about_ca_topic_score_gemma":0.000222221,"domain_scores_codex":[0.9987044,0.0002529039,0.0002686321,0.0003172353,0.0000556964,0.0004011218],"domain_scores_gemma":[0.9995443,0.00002735732,0.0001108786,0.000199216,0.00007364566,0.00004459114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006174083,0.001503712,0.005378463,0.0001161993,0.00004257943,0.000001310361,0.000751405,0.00001067404,0.9913549,0.000002580898,0.0000954176,0.0001253444],"study_design_scores_gemma":[0.0008343047,0.0002801273,0.06293347,0.00008855609,0.00003978975,0.000007582114,0.0000497929,0.000005589582,0.9343712,0.000004105822,0.001189971,0.0001954472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979702,0.0002327579,0.00004086313,0.0001605282,0.0002403303,0.0007972477,0.00001470197,0.00009680654,0.0004465305],"genre_scores_gemma":[0.9945411,0.0001007036,0.00006895769,0.00002641953,0.0001369421,0.00006833492,0.00009545722,0.00002498255,0.004937071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05755502,"threshold_uncertainty_score":0.7363418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01893229890355531,"score_gpt":0.2240232134025259,"score_spread":0.2050909144989706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}