{"id":"W1970256087","doi":"10.1371/journal.pone.0034055","title":"RNA Sensors Enable Human Mast Cell Anti-Viral Chemokine Production and IFN-Mediated Protection in Response to Antibody-Enhanced Dengue Virus Infection","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Dengue virus; Dengue fever; Biology; CXCL10; Chemokine; Virology; Antibody-dependent enhancement; Interferon; Immune system; Innate immune system; Virus; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002085189,0.0002889448,0.0002487867,0.0001184041,0.0001144531,0.0002264585,0.0001508623,0.0002775712,0.001275125],"category_scores_gemma":[0.000136157,0.0001466442,0.0002855351,0.0001167263,0.0001458695,0.0002041654,0.0001781823,0.0004013018,0.0003489579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001915986,"about_ca_system_score_gemma":0.0001038052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00018001,"about_ca_topic_score_gemma":0.0002667788,"domain_scores_codex":[0.999779,0.00003132161,0.00002740097,0.00004845369,0.00005121431,0.00006248585],"domain_scores_gemma":[0.9999372,0.00001598571,0.00001878951,0.000009804632,0.000008157019,0.00001004371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009123851,0.000008464784,0.00004726525,0.00001767484,0.000001816837,0.00001615906,0.000007350202,0.00001551635,0.9994536,0.00001825724,0.0000133542,0.0003094094],"study_design_scores_gemma":[0.00001711276,0.0002288837,0.003128566,0.000003441244,0.00001013404,0.0001299983,0.0000169718,0.0004049239,0.9950969,0.00001913839,0.0009410031,0.000003048418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995191,0.001587084,0.001897163,0.00006290917,0.00003548902,0.00004331609,0.0004593273,0.00004772282,0.0006761607],"genre_scores_gemma":[0.9948049,0.0006673624,0.001946712,0.00005200281,0.00001324447,0.00005213893,0.001034996,0.000008520932,0.001420172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001275125,"threshold_uncertainty_score":0.004265726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01893229890355531,"score_gpt":0.2240232134025259,"score_spread":0.2050909144989706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}