{"id":"W1970277994","doi":"10.1016/s0264-410x(01)00441-8","title":"Construction of recombinant targeting immunogens incorporating an HIV-1 neutralizing epitope into sites of differing conformational constraint","year":2002,"lang":"en","type":"article","venue":"Vaccine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital; Canada Research Chairs; University of Toronto","funders":"Ontario HIV Treatment Network","keywords":"Epitope; Recombinant DNA; Virology; Human immunodeficiency virus (HIV); AIDS Vaccines; Immunogenicity; HIV vaccine; Computational biology; Epitope mapping; Constraint (computer-aided design); Biology; Antibody; Immunology; Genetics; Vaccine trial; Gene; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002079712,0.0001191013,0.0002742813,0.0001269118,0.0001437897,0.000007451884,0.0001003431,0.00009065715,0.0008863848],"category_scores_gemma":[0.00007494278,0.00010113,0.00005877661,0.0001127329,0.00008040159,0.0001606793,0.00005156187,0.0001522563,0.00007963945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003323067,"about_ca_system_score_gemma":0.00002363258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001243222,"about_ca_topic_score_gemma":0.00001210287,"domain_scores_codex":[0.9990133,0.0001049323,0.000490301,0.0001370659,0.00004516675,0.0002092074],"domain_scores_gemma":[0.9993281,0.00009540873,0.0002636756,0.0001462178,0.0001394325,0.00002715483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007465811,0.0001838071,0.07301166,0.00007198856,0.0001679767,0.000003768428,0.0009448643,0.00002338491,0.9053047,0.002559446,0.0002264269,0.01742735],"study_design_scores_gemma":[0.006048322,0.001260385,0.03796029,0.0002074041,0.00007228852,0.0002434717,0.004006621,0.0008866502,0.9468943,0.0006441118,0.001417959,0.0003581817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977829,0.001185546,0.0001611706,0.0001236226,0.0001869052,0.0001621611,0.00004559458,0.00002657857,0.0003254888],"genre_scores_gemma":[0.9968299,0.000116675,0.002580361,0.000006654419,0.00001509509,0.000008431228,0.0003832405,0.000006768363,0.00005289045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04158964,"threshold_uncertainty_score":0.9705292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01864992153265207,"score_gpt":0.2450508806334676,"score_spread":0.2264009591008155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}