{"id":"W1970291191","doi":"10.1074/jbc.m114.578435","title":"Conformational Analysis of the Streptococcus pneumoniae Hyaluronate Lyase and Characterization of Its Hyaluronan-specific Carbohydrate-binding Module","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Center for Research Resources; China Scholarship Council; Engineering and Physical Sciences Research Council; Canadian Institutes of Health Research; National Institutes of Health; Wellcome Trust","keywords":"Isothermal titration calorimetry; Chemistry; Biochemistry; Glycan; Dimer; Streptococcus pneumoniae; Monomer; Polymer; Glycoprotein; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001153547,0.0002182211,0.000111417,0.0001024039,0.00009597026,0.0001641733,0.0001938021,0.0001509334,0.0005270608],"category_scores_gemma":[0.0002898515,0.00007817459,0.0001822312,0.0001959011,0.0001460505,0.000101756,0.0001134792,0.000314041,0.0001788275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002567023,"about_ca_system_score_gemma":0.0001978285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001080597,"about_ca_topic_score_gemma":0.0009404684,"domain_scores_codex":[0.9999382,0.00001423637,0.000005276682,0.00001055607,0.00001856514,0.00001308015],"domain_scores_gemma":[0.9999044,0.00002671669,0.00001804791,0.00001253414,0.00001746454,0.00002081265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002069176,0.00004441722,0.001140167,0.0000284549,0.00001239594,0.00006890873,0.00004481407,0.0004468104,0.996181,0.000152608,0.00003886177,0.00163477],"study_design_scores_gemma":[0.00002286778,0.0004128444,0.02294645,0.000009824115,0.0000299545,0.0004136713,0.00009370683,0.005699174,0.9681891,0.0001407404,0.002025383,0.00001629316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984566,0.0001936642,0.0009251215,0.00002899573,0.000003428411,0.000004541256,0.0001430281,0.000004751853,0.0002398921],"genre_scores_gemma":[0.9974994,0.0001551276,0.001048404,0.0000286952,0.000002435433,0.000007123338,0.0006911168,0.00000580993,0.0005618213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001080597,"threshold_uncertainty_score":0.002148569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01609587838805837,"score_gpt":0.2456173278243573,"score_spread":0.2295214494362989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}