{"id":"W1970303002","doi":"10.1152/ajpendo.00478.2007","title":"Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic β-cells","year":2008,"lang":"en","type":"article","venue":"American Journal of Physiology-Endocrinology and Metabolism","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Apoptosis; Unfolded protein response; Endoplasmic reticulum; Thapsigargin; Tunicamycin; Endocrinology; Internal medicine; Cell biology; Pancreatic islets; Cell culture; Chemistry; Biology; Islet; Medicine; Biochemistry; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001311833,0.0001575948,0.0009740272,0.0004856675,0.00003352814,0.000002137538,0.00009132746,0.00006573655,0.00004508653],"category_scores_gemma":[0.0005296706,0.0001229544,0.00006495947,0.0003056843,0.0005733612,0.00007782775,0.00006096396,0.0003460527,0.000001036005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000271368,"about_ca_system_score_gemma":0.0001143917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001319744,"about_ca_topic_score_gemma":0.000003993037,"domain_scores_codex":[0.9984695,0.0004016538,0.0005252703,0.0002007428,0.0001152406,0.0002875657],"domain_scores_gemma":[0.9988407,0.0004304128,0.0003042864,0.0001854017,0.000106033,0.0001330905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005788698,0.0002373026,0.0718905,0.00002517154,0.0001157921,0.00001122511,0.0004507575,0.00001480657,0.9195406,0.00005680939,0.00003226448,0.001836123],"study_design_scores_gemma":[0.004023446,0.0009780363,0.8201483,0.00008977798,0.00008414362,0.0000645129,0.0003560942,0.00001478317,0.1739822,0.00009122806,0.00008648417,0.00008104516],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986637,0.0002944353,0.00005361021,0.0007007436,0.0001104256,0.0001416845,0.000007910894,0.000006707995,0.00002077295],"genre_scores_gemma":[0.9975069,0.001127417,0.0008638194,0.0003841897,0.00007323454,0.000008583263,0.000002360084,0.000009542922,0.00002391503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7482578,"threshold_uncertainty_score":0.5013933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01083508915207694,"score_gpt":0.2487065874733021,"score_spread":0.2378714983212251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}