{"id":"W1970329005","doi":"10.1038/labinvest.3780421","title":"ABCA1 mRNA and Protein Distribution Patterns Predict Multiple Different Roles and Levels of Regulation","year":2002,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":299,"is_retracted":false,"has_abstract":false,"ca_institutions":"Xenon Pharmaceuticals (Canada); St. Paul's Hospital; University of British Columbia; Providence Health Care","funders":"Canadian Institutes of Health Research; BC Children's Hospital; Heart and Stroke Foundation of Canada","keywords":"ABCA1; Biology; Messenger RNA; In situ hybridization; Gene expression; Western blot; Endocrinology; Internal medicine; Tangier disease; Northern blot; Molecular biology; Gene; Genetics; Transporter; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001128541,0.0001216176,0.0001999984,0.00005124863,0.00005291093,0.00001796796,0.0000219707,0.00009341859,0.00002755075],"category_scores_gemma":[0.000140427,0.000103306,0.00001717731,0.000117014,0.000121644,0.0001803913,0.00001880396,0.00009735201,0.000001472486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002394465,"about_ca_system_score_gemma":0.00001378604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001208911,"about_ca_topic_score_gemma":0.00001687669,"domain_scores_codex":[0.9991779,0.00007045386,0.000254419,0.0001941667,0.0001972916,0.0001057305],"domain_scores_gemma":[0.9994261,0.00002355293,0.0001392945,0.000151875,0.000124047,0.0001351798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002965676,0.00006245339,0.5234433,0.0002955661,0.00002184464,0.000001000902,0.0008551561,0.00000252286,0.4670409,0.000468233,0.0001268512,0.007652512],"study_design_scores_gemma":[0.001196924,0.00008738137,0.8842844,0.0002315998,0.00005242589,0.000003258605,0.00005406289,0.003695396,0.1095233,0.0002081995,0.0005821935,0.00008090959],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978477,0.0004259571,0.0003111125,0.0005764374,0.00005556839,0.0004295653,0.0002966251,0.00004271143,0.00001426873],"genre_scores_gemma":[0.999303,0.000042391,0.0001495986,0.0001018466,0.0001510826,0.00002730419,0.0001319633,0.00001142702,0.00008132886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.360841,"threshold_uncertainty_score":0.4212697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02044510436157495,"score_gpt":0.2153542660257601,"score_spread":0.1949091616641852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}