{"id":"W1970347605","doi":"10.1186/1742-2094-8-92","title":"TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease","year":2011,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":272,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Eye Institute; National Institute on Aging; National Institutes of Health; Alzheimer's Association","keywords":"Microglia; TLR4; Proinflammatory cytokine; Neuroinflammation; Innate immune system; Chemokine; Immunology; TREM2; Neurodegeneration; Receptor; Cognitive decline; Biology; Cell biology; Medicine; Immune system; Inflammation; Pathology; Internal medicine; Disease; Dementia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002649087,0.0001974741,0.0002636398,0.0005429871,0.0001026574,0.00005750447,0.0001372252,0.00005678363,0.00001206051],"category_scores_gemma":[0.001419817,0.0001917358,0.0000785697,0.0002576376,0.0000820904,0.00129063,0.00004077637,0.0001947939,0.000003388541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001907828,"about_ca_system_score_gemma":0.0001358351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006994861,"about_ca_topic_score_gemma":0.000007085159,"domain_scores_codex":[0.9978033,0.0003516792,0.0009581554,0.0002769424,0.00044067,0.0001691997],"domain_scores_gemma":[0.9980327,0.0002450072,0.001141316,0.0001166823,0.0003069949,0.0001573218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006071816,0.0001667472,0.0001616256,0.00002567888,0.000006343591,0.00005125731,0.0008553919,0.00194833,0.9937593,0.0009489196,0.000006146139,0.001463096],"study_design_scores_gemma":[0.001057242,0.0002182448,0.003708482,0.00008674429,0.00005852126,0.00009734159,0.0000801132,0.01747505,0.975901,0.001168458,6.833982e-7,0.0001481403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976223,0.000034625,0.001613815,0.0001367512,0.00009042099,0.0003717447,0.00002074059,0.00002810973,0.00008156591],"genre_scores_gemma":[0.9989591,0.0001471666,0.0006729933,0.00009594736,0.00005354603,0.000008690309,0.000004191701,0.00002760877,0.00003078094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0178583,"threshold_uncertainty_score":0.781876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06207040518772415,"score_gpt":0.2624517090181985,"score_spread":0.2003813038304743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}