{"id":"W1970347605","doi":"10.1186/1742-2094-8-92","title":"TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease","year":2011,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":272,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Eye Institute; National Institute on Aging; National Institutes of Health; Alzheimer's Association","keywords":"Microglia; TLR4; Proinflammatory cytokine; Neuroinflammation; Innate immune system; Chemokine; Immunology; TREM2; Neurodegeneration; Receptor; Cognitive decline; Biology; Cell biology; Medicine; Immune system; Inflammation; Pathology; Internal medicine; Disease; Dementia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004130904,0.001534124,0.001019875,0.001565525,0.0005052622,0.0005548788,0.0007069888,0.001284351,0.002464481],"category_scores_gemma":[0.0002137573,0.0005294568,0.001021533,0.0004610911,0.0006412881,0.0006007677,0.0004297848,0.001804357,0.00103018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007216724,"about_ca_system_score_gemma":0.0005222168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009572665,"about_ca_topic_score_gemma":0.001425448,"domain_scores_codex":[0.9994703,0.00006554322,0.00007061889,0.000109232,0.0001259649,0.0001583538],"domain_scores_gemma":[0.9994848,0.00002607615,0.0001883048,0.00005135024,0.00006975797,0.0001798071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001537207,0.000797829,0.0003982212,0.0001255362,0.00004453288,0.0001423006,0.00005653701,0.00009552186,0.9950472,0.00009791149,0.0002091052,0.00144814],"study_design_scores_gemma":[0.0005912428,0.006901608,0.01022179,0.00007527735,0.0002926058,0.0009301919,0.0002033679,0.001608234,0.9745164,0.0003492071,0.004265269,0.00004476893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917617,0.002319358,0.00195325,0.00047279,0.0001584407,0.0001086303,0.00129129,0.000381696,0.001552962],"genre_scores_gemma":[0.978969,0.002880448,0.005242412,0.0003861686,0.00008701102,0.0005769874,0.002088607,0.0001425079,0.009626886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002464481,"threshold_uncertainty_score":0.008244455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06207040518772415,"score_gpt":0.2624517090181985,"score_spread":0.2003813038304743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}