{"id":"W1970361311","doi":"10.1016/j.jchromb.2004.06.009","title":"Determination of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid and its acyl glucuronide in Caco-2 monolayers by liquid chromatography with fluorescence detection: application to transport studies","year":2004,"lang":"en","type":"article","venue":"Journal of Chromatography B","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Merck Canada; Maurice and Phyllis Paykel Trust; Auckland Medical Research Foundation","keywords":"Chemistry; Chromatography; Detection limit; Bioavailability; High-performance liquid chromatography; Caco-2; Efflux; Glucuronide; Crude drug; Metabolite; Pharmacology; In vitro; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004423698,0.0004635858,0.0002948531,0.0004125092,0.0002873569,0.0002916638,0.0003224424,0.0006799411,0.0005312554],"category_scores_gemma":[0.0003862289,0.0003341085,0.0002287486,0.0003860973,0.0002371762,0.0004150063,0.0001590735,0.0006370221,0.000400435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004111209,"about_ca_system_score_gemma":0.0004426736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001921087,"about_ca_topic_score_gemma":0.002949524,"domain_scores_codex":[0.9997447,0.00008758055,0.00001524226,0.00004008208,0.00007352522,0.00003878585],"domain_scores_gemma":[0.9997522,0.00009212326,0.00004637553,0.00002700634,0.00004738265,0.00003479832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006440483,0.000007321728,0.00008213788,0.00001074339,0.000002320552,0.00001102777,0.000008443193,0.0000240779,0.9988563,0.0000288404,0.000009205119,0.0008952211],"study_design_scores_gemma":[0.000004243187,0.00008635057,0.0008721718,0.000001218471,0.000004888283,0.00003579123,0.000006655631,0.0004654817,0.9981779,0.00000847062,0.0003347619,0.000002054904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9446867,0.006168313,0.04466647,0.0002245669,0.00006317742,0.0001378585,0.0005564882,0.0003500118,0.003146396],"genre_scores_gemma":[0.9370238,0.00478499,0.05072013,0.0001076343,0.00002520512,0.000181974,0.0008862112,0.0000542363,0.006215827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001921087,"threshold_uncertainty_score":0.003819764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008481527998778993,"score_gpt":0.2516598977644939,"score_spread":0.2431783697657149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}