{"id":"W1970374191","doi":"10.1371/journal.pone.0042840","title":"Stem Cell Microvesicles Transfer Cystinosin to Human Cystinotic Cells and Reduce Cystine Accumulation In Vitro","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Biomedical Research and Pathophysiology","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Montreal Children's Hospital; McGill University","funders":"McGill University; Cystinosis Research Foundation","keywords":"Cystinosis; Stem cell; Microvesicles; Cell biology; Biology; Mesenchymal stem cell; Cystine; Chemistry; Molecular biology; Biochemistry; microRNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002555268,0.0002747835,0.0002650475,0.0002239818,0.0001014126,0.0002783659,0.0001817774,0.0002149685,0.001307753],"category_scores_gemma":[0.0002232973,0.0001157918,0.0002017476,0.0001492819,0.0002005378,0.0001077789,0.0001802998,0.0004084605,0.0003182671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002566648,"about_ca_system_score_gemma":0.0002016092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009219359,"about_ca_topic_score_gemma":0.001026699,"domain_scores_codex":[0.9998312,0.00004914247,0.00001766652,0.000026307,0.00004998981,0.0000258016],"domain_scores_gemma":[0.999818,0.00008356021,0.00002218996,0.00002527108,0.00002065524,0.00003037091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001234395,0.00005465212,0.00009894712,0.00003246983,0.000006177009,0.00003946045,0.00003715694,0.00008311247,0.9984004,0.00007829302,0.00006094351,0.0009848886],"study_design_scores_gemma":[0.00001672233,0.0002852626,0.0004982226,0.000002980778,0.000007868913,0.00004775084,0.00001142801,0.0004353329,0.9976467,0.00001718034,0.001029354,0.000001052766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933335,0.001350862,0.003132072,0.0001283946,0.00004910814,0.00006355175,0.0002876,0.00009274296,0.0015621],"genre_scores_gemma":[0.9923046,0.0008141739,0.002422929,0.00005516841,0.00001858782,0.00005003863,0.001001149,0.00002976803,0.003303582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001307753,"threshold_uncertainty_score":0.004374862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1053103216311135,"score_gpt":0.3142963972518055,"score_spread":0.208986075620692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}