{"id":"W1970374191","doi":"10.1371/journal.pone.0042840","title":"Stem Cell Microvesicles Transfer Cystinosin to Human Cystinotic Cells and Reduce Cystine Accumulation In Vitro","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Biomedical Research and Pathophysiology","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Montreal Children's Hospital; McGill University","funders":"McGill University; Cystinosis Research Foundation","keywords":"Cystinosis; Stem cell; Microvesicles; Cell biology; Biology; Mesenchymal stem cell; Cystine; Chemistry; Molecular biology; Biochemistry; microRNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003165822,0.0001455854,0.0003583351,0.000185392,0.00005322064,0.00001148676,0.00007438078,0.0001320038,0.00006249836],"category_scores_gemma":[0.00005214043,0.0001274632,0.0000324471,0.0002526326,0.0000851166,0.00007400232,0.00004264279,0.0002814132,0.0001098938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005488466,"about_ca_system_score_gemma":0.00003956246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000616849,"about_ca_topic_score_gemma":0.00000372923,"domain_scores_codex":[0.998513,0.0001112875,0.0002810577,0.0002590611,0.0003212363,0.0005142943],"domain_scores_gemma":[0.9990073,0.0001713295,0.00002312252,0.0001989057,0.00005776918,0.0005416042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005752553,0.001546534,0.001576696,0.0004514484,0.00002183142,0.00001676369,0.0003715159,3.382502e-7,0.9925779,0.00001093062,0.00007284118,0.00277791],"study_design_scores_gemma":[0.001366953,0.0004575487,0.05128218,0.0002157583,0.00006288273,0.000004924077,0.00004728954,0.00009683959,0.9462431,0.00002049556,0.00007667112,0.0001253603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978039,0.0004176556,0.00007112254,0.0006363497,0.00002733596,0.0006272186,0.00002557678,0.00003503827,0.0003558348],"genre_scores_gemma":[0.9967335,0.00002446784,0.001978551,0.0003902915,0.0002819049,0.00003035098,0.00004698248,0.00002370995,0.0004901826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04970548,"threshold_uncertainty_score":0.5197799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1053103216311135,"score_gpt":0.3142963972518055,"score_spread":0.208986075620692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}