{"id":"W1970389466","doi":"10.1007/s00228-012-1407-2","title":"The evaluation of potential pharmacokinetic interaction between sirolimus and tacrolimus in healthy volunteers","year":2012,"lang":"en","type":"article","venue":"European Journal of Clinical Pharmacology","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"Pfizer","keywords":"Tacrolimus; Sirolimus; Pharmacokinetics; Pharmacology; Medicine; Dosing; Crossover study; Drug interaction; Antibacterial agent; Urology; Internal medicine; Chemistry; Antibiotics; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005837788,0.00008951616,0.0003662129,0.0001054996,0.0000387943,0.000005228,0.00007501151,0.0000287991,0.00008040106],"category_scores_gemma":[0.0001740029,0.00005678503,0.0001410894,0.0000827663,0.0001108547,0.0001110092,0.00001741679,0.000437974,0.00001099917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003551691,"about_ca_system_score_gemma":0.0000735892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003016738,"about_ca_topic_score_gemma":4.847184e-7,"domain_scores_codex":[0.9961826,0.001951389,0.001273825,0.00008589858,0.0003214068,0.0001848477],"domain_scores_gemma":[0.9982404,0.0006641201,0.000601905,0.00005637365,0.0002212487,0.0002159461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01122629,0.0009136104,0.6647556,0.0001168412,0.000996475,0.0001775773,0.0004605596,0.0004236744,0.003049753,0.000005993679,0.0005673554,0.3173063],"study_design_scores_gemma":[0.01660913,0.001544841,0.9764143,0.00006730839,0.001274035,0.0002377766,0.00005726887,0.0007872353,0.0002725612,0.000009238599,0.002680351,0.00004590358],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939892,0.001163081,0.0001299145,0.001746444,0.002072201,0.0002158669,0.000002905746,0.000003019434,0.0006773177],"genre_scores_gemma":[0.9961255,0.001910157,0.0001271524,0.0005597745,0.001243018,0.000001070925,0.000003072669,0.00001261034,0.00001761243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3172604,"threshold_uncertainty_score":0.2315626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1473955380876636,"score_gpt":0.4972464094861667,"score_spread":0.349850871398503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}