{"id":"W1970393648","doi":"10.1177/1352458509106230","title":"Serial combination therapy: is immune modulation in multiple sclerosis enhanced by initial immune suppression?","year":2009,"lang":"en","type":"article","venue":"Multiple Sclerosis Journal","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of British Columbia; University of Ottawa; Montreal Neurological Institute and Hospital","funders":"","keywords":"Mitoxantrone; Immune system; Multiple sclerosis; Medicine; Immune modulation; Antibody; Immunology; Glatiramer acetate; Combination therapy; Immunotherapy; Oncology; Internal medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001543479,0.0007082088,0.001251401,0.0007652139,0.0009719097,0.0003581091,0.0005428932,0.0004411498,0.0006932557],"category_scores_gemma":[0.001392507,0.0006284229,0.0005576785,0.0009686298,0.0002562581,0.001097006,0.0001719376,0.001504172,0.00007448214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006770089,"about_ca_system_score_gemma":0.0001921232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002918852,"about_ca_topic_score_gemma":0.00004077231,"domain_scores_codex":[0.9936239,0.0005619413,0.001864703,0.0008404611,0.001791527,0.001317521],"domain_scores_gemma":[0.996779,0.000465011,0.000673027,0.0007478557,0.0008084584,0.0005266048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002907898,0.00178662,0.01315369,0.00002316844,0.000130531,0.000006451555,0.001695789,0.0001684878,0.8440691,0.000003175863,0.002593067,0.1334621],"study_design_scores_gemma":[0.02364196,0.0008814913,0.6121704,0.0007564076,0.00002703403,0.00001163702,0.0002796946,0.007013274,0.3543973,0.00007519922,0.0003194642,0.0004261362],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903789,0.001557267,0.001021186,0.003970446,0.000887476,0.001679838,0.0001058003,0.0001554189,0.0002437225],"genre_scores_gemma":[0.9892646,0.007360932,0.001535504,0.0005936334,0.0006514654,0.000119783,0.0002070376,0.00009609592,0.0001709192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5990167,"threshold_uncertainty_score":0.9996167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0952274905675262,"score_gpt":0.3188835299187216,"score_spread":0.2236560393511954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}