{"id":"W1970393648","doi":"10.1177/1352458509106230","title":"Serial combination therapy: is immune modulation in multiple sclerosis enhanced by initial immune suppression?","year":2009,"lang":"en","type":"article","venue":"Multiple Sclerosis Journal","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of British Columbia; University of Ottawa; Montreal Neurological Institute and Hospital","funders":"","keywords":"Mitoxantrone; Immune system; Multiple sclerosis; Medicine; Immune modulation; Antibody; Immunology; Glatiramer acetate; Combination therapy; Immunotherapy; Oncology; Internal medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009679202,0.0003919878,0.001144147,0.0003819451,0.0001920051,0.0003352312,0.0002964527,0.000545579,0.002326826],"category_scores_gemma":[0.001012046,0.0001219838,0.0003484001,0.0002869974,0.000349386,0.0004744871,0.0001980095,0.0005214441,0.0004135553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003263695,"about_ca_system_score_gemma":0.0001955037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008963821,"about_ca_topic_score_gemma":0.0002235515,"domain_scores_codex":[0.9995984,0.0001491182,0.00003473117,0.00005683559,0.0001099104,0.00005103277],"domain_scores_gemma":[0.9993336,0.0002202104,0.0002220847,0.0001046622,0.00004834622,0.00007114816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.01664985,0.002784723,0.06931289,0.001829286,0.0007225603,0.002495324,0.0001987531,0.001288349,0.2599676,0.0007385581,0.001450941,0.6425611],"study_design_scores_gemma":[0.006392755,0.1813877,0.5196206,0.0006565087,0.002813327,0.04874496,0.0002196122,0.006662659,0.1978502,0.002853263,0.03271501,0.00008340671],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9576536,0.0329376,0.003718149,0.0005420091,0.0000965681,0.0001808451,0.00005961416,0.0001237169,0.004687971],"genre_scores_gemma":[0.995144,0.002756983,0.001137715,0.0001714367,0.0002153549,0.00004837157,0.00005404274,0.000007398691,0.0004648354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002326826,"threshold_uncertainty_score":0.007783949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0952274905675262,"score_gpt":0.3188835299187216,"score_spread":0.2236560393511954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}