{"id":"W1970426420","doi":"10.1016/j.cbpa.2012.10.024","title":"Kinetic isotope effects for studying post-translational modifying enzymes","year":2012,"lang":"en","type":"review","venue":"Current Opinion in Chemical Biology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Kinetic isotope effect; Chemistry; Catalysis; Transition state; Isotope; Reaction coordinate; Enzyme catalysis; Kinetic energy; Computational chemistry; Combinatorial chemistry; Organic chemistry; Deuterium; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002963626,0.0005132938,0.0009505507,0.0001531424,0.00005249758,0.0000203827,0.0005325523,0.0009296838,0.00001672604],"category_scores_gemma":[0.0002759008,0.000430079,0.0005661881,0.0001849393,0.0001817204,0.00000395619,0.0003532837,0.0005672172,0.00002019561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004442425,"about_ca_system_score_gemma":0.0001847827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002980892,"about_ca_topic_score_gemma":3.786795e-7,"domain_scores_codex":[0.9973519,0.000219711,0.0006410163,0.0008827348,0.0001465789,0.0007580862],"domain_scores_gemma":[0.9988853,0.0002473943,0.0001716855,0.0003869764,0.0001116722,0.0001970213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005518418,0.000261165,0.00005273426,0.01724326,0.0001034364,1.993761e-7,0.00001027281,1.870873e-7,0.03208761,0.0006099231,0.0003859637,0.9491901],"study_design_scores_gemma":[0.0006690558,0.0001474757,0.000003871163,0.002022931,0.00008904079,0.00001326359,0.000001787995,0.000005202878,0.008498108,0.0001290498,0.9879163,0.000503947],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002583962,0.9952574,0.000992054,0.00004038731,0.0016263,0.001589966,0.0001840105,0.00001668697,0.0000347444],"genre_scores_gemma":[0.001917287,0.9860637,0.0005132548,0.00002740672,0.001828654,0.001109926,0.008457288,0.00006866951,0.00001388161],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9875303,"threshold_uncertainty_score":0.9998151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1347567318929718,"score_gpt":0.4309343709370546,"score_spread":0.2961776390440827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}