{"id":"W1970436087","doi":"10.1038/nature06664","title":"The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response","year":2008,"lang":"en","type":"article","venue":"Nature","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":927,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Alberta Heritage Foundation for Medical Research; Heart and Stroke Foundation of Canada","keywords":"Innate immune system; Inflammasome; AIM2; NALP3; TLR3; TLR7; MDA5; Biology; Cell biology; TLR9; Interferon; Pattern recognition receptor; Interferon regulatory factors; Toll-like receptor; Immune system; Virology; Inflammation; Immunology; RNA; RNA interference; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005837821,0.000564802,0.0005284746,0.0005015759,0.0003092106,0.00100964,0.0002264059,0.0009007826,0.002503301],"category_scores_gemma":[0.0005584033,0.0002414044,0.0004361683,0.0002506977,0.0005875349,0.001075084,0.0008941026,0.001361299,0.001340086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005726746,"about_ca_system_score_gemma":0.0003232065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005799341,"about_ca_topic_score_gemma":0.00005896929,"domain_scores_codex":[0.9994621,0.00009740448,0.00004090705,0.0001088363,0.0002259585,0.00006492628],"domain_scores_gemma":[0.9996926,0.00004871981,0.00008575321,0.00003340283,0.0000655028,0.00007397579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005346872,0.00006959819,0.001048621,0.000306638,0.00003946033,0.0008878523,0.00007786025,0.0002692289,0.9678747,0.008177972,0.002391805,0.01832158],"study_design_scores_gemma":[0.000288592,0.001188924,0.01075584,0.0001832014,0.00007509506,0.007030327,0.0003242138,0.002989056,0.8658703,0.02144434,0.08979153,0.00005854731],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6996834,0.106416,0.1114901,0.01787127,0.007731387,0.0005022336,0.002719553,0.001639974,0.05194603],"genre_scores_gemma":[0.9331988,0.01979598,0.01977397,0.003140837,0.001411225,0.0001726813,0.001203995,0.00008072211,0.02122176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002503301,"threshold_uncertainty_score":0.008374393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004492449969380776,"score_gpt":0.2209103385902936,"score_spread":0.2164178886209128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}