{"id":"W1970443437","doi":"10.1194/jlr.d050278","title":"Development and validation of sensitive LC-MS/MS assays for quantification of HP-#x03B2;-CD in human plasma and CSF","year":2014,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health","keywords":"Chromatography; Chemistry; Human plasma; Protein precipitation; Cerebrospinal fluid; Pharmacokinetics; NPC1; Pharmacology; Medicine; Biochemistry; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004485682,0.001933873,0.000877615,0.002166186,0.0007434162,0.001453863,0.00102949,0.001795716,0.0007275046],"category_scores_gemma":[0.003747248,0.0009017487,0.0006154106,0.0009910658,0.001345715,0.0006197441,0.0008481374,0.001410669,0.0009247361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001103004,"about_ca_system_score_gemma":0.002787244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002406183,"about_ca_topic_score_gemma":0.003598528,"domain_scores_codex":[0.9932842,0.00152123,0.000654656,0.001505269,0.002746279,0.0002884036],"domain_scores_gemma":[0.9981744,0.0004730785,0.0003443062,0.0001737955,0.0006992348,0.0001351225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004037002,0.0002029967,0.001627878,0.0002981958,0.00006973402,0.0001179958,0.0001386045,0.0007192978,0.983145,0.0004896303,0.0004928137,0.01229412],"study_design_scores_gemma":[0.0000666186,0.0004559415,0.003537814,0.00005563395,0.00005377217,0.0005036675,0.00004482583,0.006535161,0.9829334,0.0002331797,0.005528978,0.00005091936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.4759647,0.01570375,0.4847918,0.000803435,0.0004502446,0.003905696,0.007070667,0.004109845,0.007199971],"genre_scores_gemma":[0.4768503,0.005846323,0.4960982,0.001397569,0.0001529659,0.006443623,0.005573081,0.000339018,0.007298965],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.004485682,"threshold_uncertainty_score":0.02372283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1115010290206356,"score_gpt":0.4069877258989419,"score_spread":0.2954866968783064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}