{"id":"W1970446320","doi":"10.1016/j.joca.2014.09.006","title":"The impact of early intra-articular administration of interleukin-1 receptor antagonist on lubricin metabolism and cartilage degeneration in an anterior cruciate ligament transection model","year":2014,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Congressionally Directed Medical Research Programs; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Center for Research Resources; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Medicine; Anakinra; Osteoarthritis; Receptor antagonist; Anterior cruciate ligament; Cartilage; Chondrocyte; Internal medicine; Interleukin; Synovial fluid; Endocrinology; Apoptosis; Interleukin 1 receptor antagonist; Receptor; Antagonist; Cytokine; Pathology; Chemistry; Anatomy; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003370417,0.0006717985,0.0007887445,0.0004665402,0.0003000445,0.0005075787,0.0003814086,0.0006761128,0.001362225],"category_scores_gemma":[0.0002461397,0.0002919278,0.0006946957,0.0002432827,0.0007208641,0.0006657629,0.000212666,0.001678198,0.0002954336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003991625,"about_ca_system_score_gemma":0.0009160584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001174272,"about_ca_topic_score_gemma":0.002638806,"domain_scores_codex":[0.9996421,0.00004373848,0.00003474382,0.00006056974,0.00005724006,0.0001615846],"domain_scores_gemma":[0.9996332,0.00004668077,0.0001024733,0.0000342699,0.00003323878,0.0001501274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02041361,0.001777623,0.0003522979,0.0001855194,0.00003673819,0.0001664699,0.00009480838,0.0001897773,0.9724897,0.0001614938,0.0001612291,0.003970763],"study_design_scores_gemma":[0.001323714,0.02604829,0.006868603,0.0000283896,0.0002945413,0.0002272148,0.0002612766,0.001466815,0.9616066,0.0001601981,0.00166791,0.00004647032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967801,0.001615145,0.0006535845,0.0001466473,0.000115587,0.00004456613,0.0001978554,0.00004808368,0.000398577],"genre_scores_gemma":[0.9940569,0.001246559,0.001186429,0.00009539988,0.00004852941,0.0001253695,0.0003200169,0.00001274447,0.002907949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001362225,"threshold_uncertainty_score":0.004557133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01021834244917705,"score_gpt":0.2565178302719867,"score_spread":0.2462994878228096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}