{"id":"W1970461091","doi":"10.1002/humu.20698","title":"Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent","year":2008,"lang":"en","type":"article","venue":"Human Mutation","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"","keywords":"CYP2A6; Nicotine; Biology; Allele; Cotinine; Population; Genetics; Genotype; Gene; Medicine; CYP1A2; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001856543,0.0003650532,0.0002309617,0.0002894795,0.0004319717,0.0002033529,0.0001188988,0.0002485922,0.001878542],"category_scores_gemma":[0.0005532288,0.0001414939,0.000153128,0.0001829352,0.0002087204,0.0001077467,0.0001348701,0.0003224946,0.0001980308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001089725,"about_ca_system_score_gemma":0.00008394687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002146967,"about_ca_topic_score_gemma":0.001334132,"domain_scores_codex":[0.9998451,0.00003609424,0.000008402993,0.00005240029,0.0000239818,0.0000339539],"domain_scores_gemma":[0.9998252,0.00003081057,0.00006011071,0.00001616608,0.00002096759,0.00004686581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004178284,0.0007649999,0.7187511,0.00004882826,0.0002017735,0.002293849,0.00159122,0.0001311005,0.2460034,0.0004582354,0.0003512883,0.0252259],"study_design_scores_gemma":[0.00007609883,0.001681309,0.985388,0.000008719563,0.0001033044,0.005007926,0.0003352786,0.000456063,0.005670194,0.0001328137,0.001126768,0.00001352776],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996792,0.00004169572,0.0001485982,0.00001067553,0.00000216503,0.000004039374,0.00002332543,0.00000205602,0.00008815803],"genre_scores_gemma":[0.9991166,0.0000405616,0.0003120124,0.00001761494,0.000006280131,0.00000497724,0.00004800647,0.000003621002,0.0004502114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002146967,"threshold_uncertainty_score":0.006284297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09492972198041459,"score_gpt":0.3917539715766921,"score_spread":0.2968242495962775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}