{"id":"W1970469966","doi":"10.1021/jo049890h","title":"Combined Directed Ortho Metalation/Cross-Coupling Strategies:  Synthesis of the Tetracyclic A/B/C/D Ring Core of the Antitumor Agent Camptothecin","year":2004,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Chemistry; Metalation; Camptothecin; Ring (chemistry); Core (optical fiber); Stereochemistry; Coupling (piping); Combinatorial chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001603991,0.0004341996,0.0002827721,0.0002185005,0.0001957766,0.0001660953,0.0004361508,0.0002650718,0.001336976],"category_scores_gemma":[0.0001123882,0.0002186816,0.0002156679,0.0001827212,0.0002097701,0.0002763525,0.0003978701,0.0004732609,0.0005855475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002770276,"about_ca_system_score_gemma":0.0003237984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005176589,"about_ca_topic_score_gemma":0.001511875,"domain_scores_codex":[0.9998487,0.00002110305,0.00001260317,0.00004042359,0.00004354547,0.00003353106],"domain_scores_gemma":[0.9999422,0.000006472771,0.00001761851,0.00001117726,0.000009132084,0.00001329739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001060469,0.00006228478,0.0001321982,0.00009950648,0.00001348276,0.0001918257,0.000045921,0.0004021423,0.9877188,0.001014204,0.0001482331,0.01006526],"study_design_scores_gemma":[0.0000358136,0.000433136,0.000528188,0.000005686386,0.00002107931,0.0007072393,0.00001392322,0.0006299124,0.9915869,0.0001638196,0.005861523,0.00001291513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9094817,0.002797593,0.06412075,0.0002070321,0.0001253453,0.0003536246,0.0003769646,0.0003370065,0.02220004],"genre_scores_gemma":[0.9575985,0.001891803,0.03398195,0.0001142303,0.00002366148,0.000115136,0.0002518539,0.00005291775,0.005969977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001336976,"threshold_uncertainty_score":0.004472554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0123813600364023,"score_gpt":0.254962404746836,"score_spread":0.2425810447104337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}