{"id":"W1970475960","doi":"10.1158/1538-7445.am2013-4594","title":"Abstract 4594: Recurrent FGFR1 hotspot mutations represent a novel therapeutic target in childhood astrocytoma.","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Medulloblastoma; Cancer research; Germline; Germline mutation; PTPN11; Biology; Noonan syndrome; Pilocytic astrocytoma; Mutation; Genetics; Medicine; Glioma; Astrocytoma; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000100492,0.0004148198,0.0003447802,0.0002797174,0.0002548091,0.0003400622,0.0002817393,0.0005549045,0.002931655],"category_scores_gemma":[0.0001369599,0.000111298,0.0002926278,0.000388962,0.0001741834,0.0001446366,0.0001716439,0.0004150549,0.001164277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009372726,"about_ca_system_score_gemma":0.0004685192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002375893,"about_ca_topic_score_gemma":0.006002819,"domain_scores_codex":[0.9999287,0.000005195539,0.000005470006,0.00001508279,0.00001916067,0.00002631993],"domain_scores_gemma":[0.9999523,0.000004919125,0.00001290634,0.000003226583,0.000006952776,0.00001978468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003629906,0.0007277981,0.03194149,0.001174437,0.0003500296,0.0200742,0.0002619691,0.004558075,0.6054112,0.001512903,0.01573068,0.3146273],"study_design_scores_gemma":[0.002289578,0.009541373,0.249242,0.0003702979,0.001570758,0.1089415,0.0004617018,0.01049715,0.4294308,0.002468837,0.1850595,0.0001264097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9604341,0.01673134,0.002339051,0.0021862,0.0001904249,0.0001769226,0.002081794,0.0005699825,0.01529028],"genre_scores_gemma":[0.9892981,0.003050472,0.002098504,0.0004221433,0.00005798061,0.00003923598,0.00175199,0.00004638126,0.003234989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002931655,"threshold_uncertainty_score":0.009807348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06245572458056525,"score_gpt":0.386458965177275,"score_spread":0.3240032405967097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}