{"id":"W1970481543","doi":"10.1016/j.jalz.2012.05.238","title":"O1‐06‐06: Regulation of BACE1 expression by GSK3‐beta and its therapeutic effect on Alzheimer's disease","year":2012,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Senile plaques; Amyloid precursor protein secretase; GSK-3; Amyloid precursor protein; GSK3B; Pathogenesis; Transgene; BACE1-AS; Glycogen synthase; Tau protein; Alzheimer's disease; Signal transduction; Genetically modified mouse; Biology; Cell biology; Chemistry; Medicine; Disease; Biochemistry; Immunology; Internal medicine; Gene; Phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000248188,0.0006849483,0.0007756985,0.0004432064,0.0002386818,0.0005892754,0.0004050097,0.0004496753,0.002786971],"category_scores_gemma":[0.0001484024,0.0001663356,0.0006508634,0.0004241,0.000364859,0.0003839705,0.0002290937,0.001357662,0.00074211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002403888,"about_ca_system_score_gemma":0.0005027194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004881693,"about_ca_topic_score_gemma":0.0007092431,"domain_scores_codex":[0.9998953,0.00001454644,0.00001073967,0.00001865436,0.00001995357,0.00004085821],"domain_scores_gemma":[0.9999436,0.000005541476,0.00001141139,0.000006425344,0.0000074836,0.00002546372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01042912,0.003867382,0.0005320822,0.00120193,0.0001554395,0.0003784969,0.0001269481,0.0003831503,0.9294519,0.001118559,0.002173149,0.05018191],"study_design_scores_gemma":[0.006434104,0.02418019,0.01108706,0.0001626524,0.000433863,0.0009418065,0.0001635505,0.001706247,0.924982,0.0006962713,0.02914757,0.00006455062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9674306,0.0205921,0.001436566,0.0006695136,0.0005172361,0.0002656918,0.0009686967,0.0003218927,0.007797705],"genre_scores_gemma":[0.9748356,0.01391675,0.002267909,0.0003457153,0.0001158063,0.0003778427,0.001628919,0.00005379047,0.006457479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002786971,"threshold_uncertainty_score":0.009323299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03055863993797404,"score_gpt":0.3133437571378675,"score_spread":0.2827851171998935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}